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Publications in 2022


Alpha-peptide receptor radionuclide therapy using actinium-225 labeled somatostatin receptor agonists and antagonists

Front Med (Lausanne). 2022 Dec 7;9:1034315

Mengqi Shi, Vivianne Jakobsson, Lukas Greifenstein, Pek-Lan Khong, Xiaoyuan Chen, Richard P Baum, Jingjing Zhang


PET imaging of fibroblast activation protein in various types of cancers by using 68Ga-FAP-2286: Comparison with 18F-FDG and 68Ga-FAPI-46 in a single-center, prospective study.

J Nucl Med. 2022 Sep 2:jnumed.122.264544.

Pang Y, Zhao L, Meng T, Xu W, Lin Q, Wu H, Zhang J, Chen X, Sun L, Chen H.


Synergism of 64Cu-Labeled RGD with Anti-PD-L1 Immunotherapy for the Long-Acting Antitumor Effect.

Bioconjug Chem. 2022 Nov 16;33(11):2170-2179.

Wen X, Zeng X, Liu J, Zhang Y, Shi C, Wu X, Zhuang R, Chen X, Zhang X, Guo Z.


Development of a multi-scene universal multiple wavelet-FFT algorithm (MW-FFTA) for denoising motion artifacts in OCT-angiography in vivo imaging.

Opt Express. 2022 Sep 26;30(20):35854-35870.

Zhang Y, Li J, Liu C, Zheng K, Zhang B, Zhou Y, Dai C, Fan S, Yao Y, Zhuang R, Guo D, Huang Z, Mao J, Liang J, Yang H, Wang L, Liu G, Chen X, Zhao Q.


A Totipotent "All-In-One" Peptide Sequentially Blocks Immune Checkpoint and Reverses the Immunosuppressive Tumor Microenvironment.

Adv Mater. 2022 Oct 19:e2207330.

Zhang L, Jiang Z, Yang X, Qian Y, Wang M, Wu S, Li L, Jia F, Wang Z, Hu Z, Zhao M, Tang X, Li G, Shang H, Chen X, Wang W.


Near-infrared-II ratiometric fluorescence probes for non-invasive detection and precise navigation surgery of metastatic sentinel lymph nodes.

Theranostics. 2022 Oct 9;12(16):7191-7202.

Li M, Zheng X, Han T, Ma S, Wang Y, Sun B, Xu J, Wang X, Zhang S, Zhu S, Chen X.


Synthesis, preclinical evaluation and radiation dosimetry of a dual targeting PET tracer [68Ga]Ga-FAPI-RGD.

Theranostics. 2022 Oct 9;12(16):7180-7190.

Zang J, Wen X, Lin R, Zeng X, Wang C, Shi M, Zeng X, Zhang J, Wu X, Zhang X, Miao W, Xu P, Guo Z, Zhang J, Chen X.


Cell Wall Destruction and Internal Cascade Synergistic Antifungal Strategy for Fungal Keratitis.

ACS Nano. 2022 Nov 22;16(11):18729-18745. 

Ye Y, He J, Wang H, Li W, Wang Q, Luo C, Tang X, Chen X, Jin X, Yao K, Zhou M.


Biomimetic Yolk-Shell Nanocatalysts for Activatable Dual-Modal-Image-Guided Triple-Augmented Chemodynamic Therapy of Cancer.

ACS Nano. 2022 Nov 22;16(11):19038-19052.

Pan Y, Zhu Y, Xu C, Pan C, Shi Y, Zou J, Li Y, Hu X, Zhou B, Zhao C, Gao Q, Zhang J, Wu A, Chen X, Li J.


An Integrated Polymeric mRNA Vaccine without Inflammation Side Effects for Cellular Immunity Mediated Cancer Therapy.

Adv Mater. 2022 Nov 3:e2207471

Huang P, Jiang L, Pan H, Ding L, Zhou B, Zhao M, Zou J, Li B, Qi M, Deng H, Zhou Y, Chen X.


A single-arm, low-dose, prospective study of 177Lu-EB-PSMA radioligand therapy in patients with metastatic castration-resistant prostate cancer.

J Nucl Med. 2022 Nov 3:jnumed.122.264857.

Wang G, Zang J, Jiang Y, Liu Q, Sui H, Wang R, Fan X, Zhang J, Zhu Z, Chen X.


Development of nanotechnology-mediated precision radiotherapy for anti-metastasis and radioprotection.

Chem Soc Rev. 2022 Nov 28;51(23):9759-9830. 

Pan Y, Tang W, Fan W, Zhang J, Chen X.


Responsive Accumulation of Nanohybrids to Boost NIR-Phototheranostics for Specific Tumor Imaging and Glutathione Depletion-Enhanced Synergistic Therapy.

Adv Sci (Weinh). 2022 Nov 14;10(1):e2205208.

He L, Zheng N, Wang Q, Du J, Wang S, Cao Z, Wang Z, Chen G, Mu J, Liu S, Chen X.


Facile Synthesis of Weakly Ferromagnetic Organogadolinium Macrochelates-Based T1 -Weighted Magnetic Resonance Imaging Contrast Agents.

Adv Sci (Weinh). 2022 Nov 15;10(1):e2205109.

Lu Y, Liang Z, Feng J, Huang L, Guo S, Yi P, Xiong W, Chen S, Yang S, Xu Y, Li Y, Chen X, Shen Z.


In Response to Precision Medicine: Current Subcellular Targeting Strategies for Cancer Therapy.

Adv Mater. 2022 Nov 29:e2209529

Li Z, Zou J, Chen X.


Targeting the activity of T cells by membrane surface redox regulation for cancer theranostics

Nat Nanotechnol. 2022 Dec 19. doi: 10.1038/s41565-022-01261-7

Shi C, Zhang Q, Yao Y, Zeng F, Du C, Nijiati S, Wen X, Zhang X, Yang H, Chen H, Guo Z, Zhang X, Gao J, Guo W, Chen X, Zhou Z. Targeting the activity of T cells by membrane surface redox regulation for cancer theranostics. Nat Nanotechnol. 2022 Dec 19. doi: 10.1038/s41565-022-01261-7. Epub ahead of print. PMID: 36536041.


Evolution of drug regulations and regulatory innovation for anticancer drugs in China.

Acta Pharm Sin B. 2022 Dec;12(12):4365-4377

Liu Y, Zhang N, Xie C, Jiang Y, Qin Y, Zhou L, Fan Y, Ren L, Yin C, Yang H, Xie W, Zhai Q, Li G, Chen H, Chen X.


Safety and efficacy of peptide receptor radionuclide therapy with 177Lu-DOTA-EB-TATE in patients with metastatic neuroendocrine tumors

Theranostics 2022; 12(15):6437-6445.

Jiang Y, Liu Q, Wang G, Sui H, Wang R, Wang J, Zhang J, Zhu Z, Chen X.


Organic phosphorescent nanoscintillator for low-dose X-ray-induced photodynamic therapy.

Nat Commun. 2022;13(1):5091.

Wang X, Sun W, Shi H, Ma H, Niu G, Li Y, Zhi J, Yao X, Song Z, Chen L, Li S, Yang G, Zhou Z, He Y, Qu S, Wu M, Zhao Z, Yin C, Lin C, Gao J, Li Q, Zhen X, Li L, Chen X, Liu X, An Z, Chen H, Huang W.


Targeting the activity of T cells by membrane surface redox regulation for cancer theranostics

Nat Nanotechnol, in press.

Shi C, Zhang Q, Zeng F, Du C, Nijiati S, Wen X, Yang H, Guo Z, Zhang X, Gao J, Chen X, Zhou Z


A pilot study of 68 Ga-PSMA-617 PET/CT imaging and 177Lu-EB-PSMA-617 radioligand therapy in patients with adenoid cystic carcinoma.

EJNMMI Res. 2022 Aug 19;12(1):52.

Wang G, Zhou M, Zang J, Jiang Y, Chen X, Zhu Z, Chen X.


Combined 18F-FDG and 18F-Alfatide II PET May Predict Luminal B (HER2 Negative) Subtype and Nonluminal Subtype of Invasive Breast Cancer.

Mol Pharm. 2022 Aug 16. doi: 10.1021/acs.molpharmaceut.2c00547.

Wu J, Zhang X, Jia Z, Zhou X, Qi R, Ji H, Sun J, Sun C, Teng Z, Lu G, Chen X.


Cancer Nanomedicine

Nat Rev Cancer, doi: 10.1038/s41568-022-00496-9

Bhatia S, Chen X, Dobrovolskaia M, Lammers T


Management of fluorescent organic/inorganic nanohybrids for biomedical applications in the NIR-II region

Li B, Zhao M, Lin J, Huang P, Chen X


Microfluidics-Assisted Fluorescence Mapping of DNA Phosphorothioation

Anal Chem, 2022 Jul 26;94(29):10479-10486

Huang Q, Chen X, Meng Q-F, Yue L, Jiang W, Zhao X-Z, Rao L, Chen X, S chen


Harnessing Immune Response Using Reactive Oxygen Species-Generating/Eliminating Inorganic Biomaterials for Disease Treatment

Adv Drug Deliv Rev, 2022 Jul 16;188:114456

Zhao C, Deng H, Chen X


Super-stable cyanine@albumin fluorophore for enhanced NIR-II bioimaging

Theranostics. 2022 May 26;12(10):4536-4547

Bai L, Hu Z, Han T, Wang Y, Xu J, Jiang G, Feng X, Sun B, Liu X, Tian R, Sun H, Zhang S, Chen X, Zhu S.


Nanomaterial-Mediated Ablation Therapy for Cancer Stem Cells

Matter, 2022;5: 1367-1390.

Pan Y, Liu L, Rao L, Chen X


Chiral gold clusters functionalized two-dimensional nanoparticle films to regulate the adhesion and differentiation of stem cells

J Colloid Interface Sci. 2022;625:831-838.

Kang X, Wang Y, Cai XL, Hua Y, Shao ZH, Chen X, Zhao X, Zang SQ.


Cucurbituril-based Supramolecular Polymers for Biomedical Applications

Angew Chem Int Ed Engl. 2022 Jun 28. doi: 10.1002/anie.202206763.

Wang Z, Sun C, Yang K, Chen X, Wang R.


The Roles of Polymers in mRNA Delivery

Matter, 2022;5:1670-1699.

Huang P, Deng H, Zhou Y, Chen X


Levonorgestrel-protected Au8 and Au10 clusters with different antimicrobial abilities

J Mater Chem B. 2022 Jun 20. doi: 10.1039/d2tb00533f.

Wang Y, Hua Y, Shao ZH, Chen X, Zhao X, Zang SQ.


Composition-Dependent Enzyme Mimicking Activity and Radiosensitizing Effect of Bimetallic Clusters to Modulate Tumor Hypoxia for Enhanced Cancer Therapy

Adv Mater. 2022:e2203734.

Hua Y, Huang JH, Shao ZH, Luo XM, Wang ZY, Liu JQ, Zhao X, Chen X, Zang SQ.


PD-L1-Targeted Radionuclide Therapy Combined with αPD-L1 Antibody Immunotherapy Synergistically Improves the Antitumor Effect

Mol Pharm. 2022 Jun 2. doi: 10.1021/acs.molpharmaceut.2c00281.

Wen X, Zeng X, Cheng X, Zeng X, Liu J, Zhang Y, Li Y, Chen H, Huang J, Guo Z, Chen X, Zhang X.


Rational Design and Pharmacomodulation of Protein-Binding Theranostic Radioligands for Targeting the Fibroblast Activation Protein

J Med Chem. 2022 Jun 5. doi: 10.1021/acs.jmedchem.1c02162.

Meng L, Fang J, Zhao L, Wang T, Yuan P, Zhao Z, Zhuang R, Lin Q, Chen H, Chen X, Zhang X, Guo Z.


A genetic engineering strategy for editing near-infrared-II fluorophores.

Nat Commun. 2022 May 23;13(1):2853.

Tian R, Feng X, Wei L, Dai D, Ma Y, Pan H, Ge S, Bai L, Ke C, Liu Y, Lang L, Zhu S, Sun H, Yu Y, Chen X.


Protective Effect of Platinum Nano-antioxidant and Nitric Oxide Against Hepatic Ischemia-Reperfusion Injury

Nat Commun, 2022;13(1):2513

Mu J, Li C, Shi Y, Liu G, Zou J, Zhang D, Jiang C, Wang X, He L, Huang P, Yin Y, Chen X


Reactive Oxygen Species Scavenging Nanomedicine for The Treatment of Ischemic Heart Disease

Adv Mater. 2022:e2202169.

Zhang Z, Dalan R, Hu Z, Wang JW, Chew NW, Poh KK, Tan RS, Soong TW, Dai Y, Ye L, Chen X.


Photoacoustic Imaging-Guided Synergistic Photothermal/Radiotherapy Using Plasmonic Bi/Bi2O3-x Nanoparticles

Huang X, Zha F, Zou J, Li Y, Wang F, Chen X


Smart Mushroom-Inspired Imprintable and Lightly Detachable (MILD) Microneedle Patterns for Effective COVID-19 Vaccination and Decentralized Information Storage

ACS Nano. 2022 Apr 22. doi: 10.1021/acsnano.1c10718.

Li Q, Xu R, Fan H, Xu J, Xu Y, Cao P, Zhang Y, Liang T, Zhang Y, Chen W, Wang Z, Wang L, Chen X


A nanovaccine for antigen self-presentation and immunosuppression reversal as a personalized cancer immunotherapy strategy

Nat Nanotechnol. 2022 Apr 11. doi: 10.1038/s41565-022-01098-0.

Liu C, Liu X, Xiang X, Pang X, Chen S, Zhang Y, Ren E, Zhang L, Liu X, Lv P, Wang X, Luo W, Xia N, Chen X, Liu G


Avoiding the self-nucleation interference: a pH-regulated gold in situ growth strategy to enable ultrasensitive immunochromatographic diagnostics

Theranostics. 2022;12(6):2801-2810.

Duan H, Ma T, Huang X, Gao B, Zheng L, Chen X, Xiong Y, Chen X


Combined Probe Strategy to Increase the Enzymatic Digestion Rate and Accelerate the Renal Radioactivity Clearance of Peptide Radiotracers

Mol Pharm. 2022 Mar 31. doi: 10.1021/acs.molpharmaceut.2c00051.

Zhang M, Ye J, Xie Z, Wang Y, Ma W, Kang F, Yang W, Wang J, Chen X


A paradigm of cancer immunotherapy based on 2-[18F]FDG and anti-PD-L1 mAb combination to enhance the anti-tumor effect

Clin Cancer Res. 2022 Mar 23:clincanres.0159.2022.

Wen X, Shi C, Zeng X, Zhao L, Yao L, Liu Z, Feng L, Zhang D, Huang J, Li Y, Lin Q, Chen H, Zhuang R, Chen X, Zhang X, Guo Z.


Preliminary Clinical Application of RGD-Containing Peptides as PET Radiotracers for Imaging Tumors

Front Oncol. 2022;12:837952.

Li L, Chen X, Yu J, Yuan S.


A tumor microenvironment dual responsive contrast agent for contrary contrast-magnetic resonance imaging and specific chemotherapy of tumors

Nanoscale Horiz. 2022 Feb 25. doi: 10.1039/d1nh00632k.

Lu Y, Feng J, Liang Z, Lu X, Guo S, Huang L, Xiong W, Chen S, Zhou H, Ma X, Xu Y, Qiu X, Wu A, Chen X, Shen Z.


A super-stable homogeneous Lipiodol-hydrophilic chemodrug formulation for treatment of hepatocellular carcinoma

Theranostics. 2022;12(4):1769-1782.

He P, Ren E, Chen B, Chen H, Cheng H, Gao X, Liang X, Liu H, Li J, Li B, Chen A, Chu C, Chen X, Mao J, Zhang Y, Liu G.


Recent advances in biomaterial-boosted adoptive cell therapy

Chem Soc Rev. 2022 Feb 16. doi: 10.1039/d1cs00786f.

Xue Y, Che J, Ji X, Li Y, Xie J, Chen X.


A "Self-Checking" pH/Viscosity-Activatable NIR-II Molecule for Real-Time Evaluation of Photothermal Therapy Efficacy

Angew Chem Int Ed Engl. 2022 Feb 15. doi: 10.1002/anie.202200025.

Li B, Liu H, He Y, Zhao M, Ge C, Younis MR, Huang P, Chen X, Lin J.


Antibody-Incorporated Nanomedicines for Cancer Therapy

Adv Mater. 2022 Feb 10:e2109210. doi: 10.1002/adma.202109210.

Wu SY, Wu FG, Chen X.


18F-Alfatide II for the evaluation of axillary lymph nodes in breast cancer patients: comparison with 18F-FDG

Eur J Nucl Med Mol Imaging. 2022 Feb 9. doi: 10.1007/s00259-021-05333-z.

Wu J, Tian J, Zhang Y, Ji H, Sun J, Wang X, Sun C, Wang L, Teng Z, Lu G, Zhu H, Chen X.


Noninvasive Dual-Modality Photoacoustic-Ultrasonic Imaging to Detect Mammalian Embryo Abnormalities after Prenatal Exposure to Methylmercury Chloride (MMC): A Mouse Study

Environ Health Perspect. 2022;130(2):27002.

Qiu Q, Huang Y, Zhang B, Huang D, Chen X, Fan Z, Lin J, Yang W, Wang K, Qu N, Li J, Li Z, Huang J, Li S, Zhang J, Liu G, Rui G, Chen X, Zhao Q


Hybrid Membrane-Decorated Prussian Blue for Effective Cancer Immunotherapy via Tumor-Associated Macrophages Polarization and Hypoxia Relief

Adv Mater. 2022 Feb 1:e2200389.

Hou L, Gongu X, Zhang JH, Yang W, Chen X


Metal-free bioorthogonal click chemistry in cancer theranostics

Chem Soc Rev. 2022 Jan 20. doi: 10.1039/d1cs00451d.

Wu D, Yang K, Zhang Z, Feng Y, Rao L, Chen X, Yu G.


Evans blue-modified radiolabeled fibroblast activation protein inhibitor as long-acting cancer therapeutics

Theranostics. 2022;12(1):422-433.

Wen X, Xu P, Shi M, Liu J, Zeng X, Zhang Y, Shi C, Li J, Guo Z, Zhang X, Khong PL, Chen X.


Near-infrared probes for luminescence lifetime imaging

Nanotheranostics. 2022;6(1):91-102.

Li B, Lin J, Huang P, Chen X.


Coordinating the mechanism of actions of ferroptosis and photothermal effect for cancer theranostics

Angew Chem Int Ed Engl. 2021 Dec 21. doi: 10.1002/anie.202112925.

Zeng F, Tang L, Zhang Q, Shi C, Huang Z, Nijiati S, Chen X, Zhou Z.


Biodegradable Metal-Organic Framework-Gated Organosilica for Tumor Microenvironment-Unlocked Glutathione Depletion-Enhanced Synergistic Therapy

Adv Mater. 2021 Dec 13:e2107560. doi: 10.1002/adma.202107560.

Ma Y, Su Z, Zhou L, He L, Hou Z, Zou J, Cai Y, Chang D, Xie J, Zhu C, Fan W, Chen X, Ju S.


Prostate-specific membrane antigen radioligand therapy using 177Lu-PSMA I&T and 177Lu-PSMA-617 in patients with metastatic castration-resistant prostate cancer: comparison of safety, biodistribution and dosimetry

J Nucl Med. 2021 Dec 9:jnumed.121.262713. doi: 10.2967/jnumed.121.262713.

Schuchardt C, Zhang J, Kulkarni HR, Chen X, Mueller D, Baum RP.


The Chemistry of Organic Contrast Agents in the NIR-II Window

Angew Chem Int Ed Engl. 2021 Dec 6. doi: 10.1002/anie.202114722.

Mu J, Xiao M, Shi Y, Geng X, Li H, Yin Y, Chen X.


Nanomaterials targeting tumor associated macrophages for cancer immunotherapy

J Control Release. 2022;341:272-284.

Zhao C, Pang X, Yang Z, Wang S, Deng H, Chen X.


A generic self-assembly approach towards phototheranostics for NIR-II fluorescence imaging and phototherapy

Acta Biomater. 2021 Nov 20:S1742-7061(21)00769-8.

Cui C, Wang C, Fu Q, Song J, Zou J, Li L, Zhu J, Huang W, Li L, Yang Z, Chen X.

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