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Publications in 2021


A multifunctional AIE gold cluster-based theranostic system: tumor-targeted imaging and Fenton reaction-assisted enhanced radiotherapy

J Nanobiotechnology. 2021;19(1):438.

Hua Y, Wang Y, Kang X, Xu F, Han Z, Zhang C, Wang ZY, Liu JQ, Zhao X, Chen X, Zang SQ.


Multi-Responsive Bottlebrush-Like Unimolecules Self-Assembled Nano-Riceball for Synergistic SonoChemotherapy

Small Methods. 2021;5(3):e2000416.

Shi X, Zhang Y, Tian Y, Xu S, Ren E, Bai S, Chen X, Chu C, Xu Z, Liu G.


Repurposing ICG enables MR/PA imaging signal amplification and iron depletion for iron-overload disorders

Sci Adv. 2021;7(51):eabl5862.

Lin H, Zhou Y, Wang J, Wang H, Yao T, Chen H, Zheng H, Zhang Y, Ren E, Jiang L, Chu C, Chen X, Mao J, Wang F, Liu G.


NIR-II emissive AIEgen photosensitizers enable ultrasensitive imaging-guided surgery and phototherapy to fully inhibit orthotopic hepatic tumors

J Nanobiotechnology. 2021;19(1):419.

Jia R, Xu H, Wang C, Su L, Jing J, Xu S, Zhou Y, Sun W, Song J, Chen X, Chen H.


Ligand Engineering of Titanium-Oxo Nanoclusters for Cerenkov Radiation-Reinforced Photo/Chemodynamic Tumor Therapy

ACS Appl Mater Interfaces. 2021;13(46):54727-54738.

Li J, Dai S, Qin R, Shi C, Ming J, Zeng X, Wen X, Zhuang R, Chen X, Guo Z, Zhang X.


Redox-Activated Contrast-Enhanced T1-Weighted Imaging Visualizes Glutathione-Mediated Biotransformation Dynamics in the Liver

ACS Nano. 2021;15:17831-17841.

Liu K, Kang B, Luo X, Yang Z, Sun C, Li A, Fan Y, Chen X, Gao J, Lin H.


Aptamer-based biosensors and application in tumor theranostics

Cancer Sci. 2022;113:7-16.

Mo T, Liu X, Luo Y, Zhong L, Zhang Z, Li T, Gan L, Liu X, Li L, Wang H, Sun X, Fan D, Qian Z, Wu P, Chen X.


Intelligent Pore Switch of Hollow Mesoporous Organosilica Nanoparticles for High Contrast Magnetic Resonance Imaging and Tumor-Specific Chemotherapy

Nano Lett. 2021;21(22):9551-9559.

Huang L, Feng J, Fan W, Tang W, Rong X, Liao W, Wei Z, Xu Y, Wu A, Chen X, Shen Z.


Polyprodrug Nanomedicines: An Emerging Paradigm for Cancer Therapy

Adv Mater. 2021 Oct 25:e2107434.

Yang K, Yang Z, Yu G, Nie Z, Wang R, Chen X.


Somatostatin receptor imaging with [68Ga]Ga-DOTATATE positron emission tomography/computed tomography (PET/CT) in patients with nasopharyngeal carcinoma

Eur J Nucl Med Mol Imaging. 2021 Oct 19. doi: 10.1007/s00259-021-05587-7.

Zhao L, Pang Y, Wang Y, Chen J, Zhuang Y, Zhang J, Zhao L, Sun L, Wu H, Chen X, Lin Q, Chen H.


Genetically Programmable Fusion Cellular Vesicles for Cancer Immunotherapy

Angew Chem Int Ed Engl. 2021;60(50):26320-26326.

Meng QF, Zhao Y, Dong C, Liu L, Pan Y, Lai J, Liu Z, Yu GT, Chen X, Rao L.


Smart Chemical Engineering-based Lightweight and Miniaturized Attachable Systems for Advanced Drug Delivery and Diagnostics

Adv Mater. 2021 Oct 13:e2106701.

Chen W, Wang Z, Wang L, Chen X.


Radioiodinated 4-(p-Iodophenyl) Butanoic Acid-Modified Estradiol Derivative for ER Targeting SPECT Imaging

Anal Chem. 2021;93(41):13998-14006.

Xu D, Lin X, Zeng X, Wen X, Li J, Li Y, Huang J, Chen X, Guo Z, Zhang X.


Lung-Targeting Lysostaphin Microspheres for Methicillin-Resistant Staphylococcus aureus Pneumonia Treatment and Prevention

ACS Nano. 2021;15(10):16625-16641.

Lin X, He J, Li W, Qi Y, Hu H, Zhang D, Xu F, Chen X, Zhou M.


Manipulating Intratumoral Fenton Chemistry for Enhanced Chemodynamic and ChemodynamicSynergized Multimodal Therapy

Adv Mater. 2021 Sep 27:e2104223.

Zhou Y, Fan S, Feng L, Huang X, Chen X.


Singlet Oxygen "Afterglow" Therapy with NIR-II Fluorescent Molecules

Adv Mater. 2021 Sep 13:e2103627.

Zou J, Li L, Zhu J, Li X, Yang Z, Huang W, Chen X.


Optimization of Enzymolysis Clearance Strategy To Enhance Renal Clearance of Radioligands

Bioconjug Chem. 2021 Sep 6. doi: 10.1021/acs.bioconjchem.1c00392.

Zhang M, Ye J, Xie Z, Yan Y, Wang J, Chen X.


Endogenous dual stimuli-activated NO generation in the conventional outflow pathway for precision glaucoma therapy

Biomaterials. 2021;277:121074.

Fan W, Song M, Li L, Niu L, Chen Y, Han B, Sun X, Yang Z, Lei Y, Chen X.


Milk-derived extracellular vesicles alleviate ulcerative colitis by regulating the gut immunity and reshaping the gut microbiota

Theranostics. 2021;11(17):8570-8586.

Tong L, Hao H, Zhang Z, Lv Y, Liang X, Liu Q, Liu T, Gong P, Zhang L, Cao F, Pastorin G, Lee CN, Chen X, Wang JW, Yi H.


Fluorescence imaging of pathophysiological microenvironments.

Chem Soc Rev. 2021 Jul 1. doi: 10.1039/d1cs00083g.

Wang S, Ren WX, Hou JT, Won M, An J, Chen X, Shu J, Kim JS.


Exquisite vesicular nanomedicine by paclitaxel mediated co-assembly with camptothecin prodrug.

Angew Chem Int Ed Engl. 2021 Jul 18. doi: 10.1002/anie.202108658.

Zhou Z, Du C, Zhang Q, Yu G, Zhang F, Chen X.


Antiangiogenesis Combined with Inhibition of the Hypoxia Pathway Facilitates Low-Dose, X-rayInduced Photodynamic Therapy

ACS Nano. 2021 Jun 25. doi: 10.1021/acsnano.1c01063.

Jiang Z, He L, Yu X, Yang Z, Wu W, Wang X, Mao R, Cui D, Chen X, Li W.


Intravital Whole-Process Monitoring Thermo-Chemotherapy Via 2D Silicon Nanoplatform: A Macro Guidance and Long-Term Microscopic Precise Imaging Strategy

Adv Sci (Weinh). 2021 Jun 24:e2101242.

Huang D, Wang G, Mao J, Liu C, Fan Z, Zhang Y, Zhang B, Zhao Y, Dai C, He Y, Ma H, Liu G, Chen X, Zhao Q.


Mn3+-rich oxide/persistent luminescence nanoparticles achieve light-free generation of singlet oxygen and hydroxyl radicals for responsive imaging and tumor treatment

Theranostics. 2021 May 25;11(15):7439-7449.

Ding D, Feng Y, Qin R, Li S, Chen L, Jing J, Zhang C, Sun W, Li Y, Chen X, Chen H.


Functional Micro-/Nanomaterials for Multiplexed Biodetection

Adv Mater. 2021 Jun 17:e2004734.

7. Liu X, Wu W, Cui D, Chen X, Li W.


68Ga-NOTA-Evans Blue PET/CT findings in lymphangioleiomyomatosis compared with 99mTC-ASC lymphoscintigraphy: a prospective study.

Orphanet J Rare Dis. 2021 Jun 16;16(1):279

Hou G, Jiang Y, Xu W, Zhu Z, Huo L, Chen X, Li F, Xu KF, Cheng W.


Synthesis and Bioapplications of Ag2S Quantum Dots with Near-Infrared Fluorescence

Adv Mater. 2021 Jun 12:e2007768.

Ding C, Huang Y, Shen Z, Chen X


A Fluorinated Ionic Liquid-Based Activatable 19F MRI Platform Detects Biological Targets

Chem. 2020 May 14;6(5):1134-1148.

Zhu X, Tang X, Lin H, Shi S, Xiong H, Zhou Q, Li A, Wang Q, Chen X, Gao J.


A hypoxia responsive nanoassembly for tumor specific oxygenation and enhanced sonodynamic therapy

Biomaterials. 2021 May 3;275:120822.

Yang K, Yue L, Yu G, Rao L, Tian R, Wei J, Yang Z, Sun C, Zhang X, Xu M, Yuan Z, Chen X, Wang R.


Supramolecular Polymerization-Induced Nanoassemblies for Self-Augmented Cascade Chemotherapy and Chemodynamic Therapy of Tumour

Angew Chem Int Ed Engl. 2021 May 26. doi: 10.1002/anie.202103721.

Yang K, Yang Z, Yue L, Yu G, Zhang X, Sun C, Wei J, Rao L, Chen X, Wang R.


Photodynamic-Chemodynamic Cascade Reactions for Efficient Drug Delivery and Enhanced Combination Therapy

Adv Sci (Weinh). 2021 Apr 8;8(10):2002927.

Wang S, Yu G, Yang W, Wang Z, Jacobson O, Tian R, Deng H, Lin L, Chen X.


Extracellular vesicles as a drug delivery system:A systematic review of preclinical studies

Adv Drug Deliv Rev. 2021 May 18:S0169-409X(21)00175-7. doi: 10.1016/j.addr.2021.05.011.

Escudé Martinez de Castilla P, Tong L, Huang C, Marios Sofias A, Pastorin G, Chen X, Storm G, Schiffelers RM, Wang JW.


Beyond Photo: Xdynamic Therapies in Fighting Cancer.

Adv Mater. 2021:e2007488.

Wang S, Tian R, Zhang X, Cheng G, Yu P, Chang J, Chen X.


Bombesin-Tethered Reactive Oxygen Species (ROS)-Responsive Nanoparticles for Monomethyl Auristatin F (MMAF) Delivery

Bioengineering (Basel). 2021 Mar 29;8(4):43.

Kim J, Kim JS, Min KH, Kim YH, Chen X


Capturing Cytokines with Advanced Materials: A Potential Strategy to Tackle COVID-19 Cytokine Storm

Adv Mater. 2021 Apr 10:e2100012. doi: 10.1002/adma.202100012.

7. Meng QF, Tian R, Long H, Wu X, Lai J, Zharkova O, Wang JW, Chen X, Rao L.


Singlet Oxygen Generation in Dark-Hypoxia by Catalytic Microenvironment-Tailored Nanoreactors for NIR-II Fluorescence-Monitored Chemodynamic Therapy

Angew Chem Int Ed Engl. 2021 Apr 19. doi: 10.1002/anie.202102097.

Chen T, Hou P, Zhang Y, Ao R, Su L, Jiang Y, Zhang Y, Cai H, Wang J, Chen Q, Song J, Lin L, Yang H, Chen X.


Polyphenol-Containing Nanoparticles: Synthesis, Properties, and Therapeutic Delivery

Adv Mater. 2021 Apr 19:e2007356.

Guo Y, Sun Q, Wu FG, Dai Y, Chen X.


Rationally Programming Nanomaterials with DNA for Biomedical Applications

Adv Sci (Weinh). 2021 Feb 24;8(8):2003775.

He L, Mu J, Gang O, Chen X.


Biphasic synthesis of biodegradable urchin-like mesoporous organosilica nanoparticles for enhanced cellular internalization and precision cascaded therapy

Biomater Sci. 2021 Feb 17. doi: 10.1039/d1bm00015b.

Cheng Y, Jiao X, Wang Z, Jacobson O, Aronova MA, Ma Y, He L, Liu Y, Tang W, Deng L, Zou J, Yang Z, Zhang M, Wen Y, Fan W, Chen X


Targeted Dual Small Interfering Ribonucleic Acid Delivery via Non-Viral Polymeric Vectors for Pulmonary Fibrosis Therapy

Adv Mater. 2021:e2007798.

Ji Q, Hou J, Yong X, Gong G, Muddassir M, Tang T, Xie J, Fan W, Chen X


Supramolecular cancer nanotheranostics.

Chem Soc Rev. 2021 Feb 1. doi: 10.1039/d0cs00011f.

Zhou J, Rao L, Yu G, Cook TR, Chen X, Huang F.


Pnictogen Semimetal (Sb, Bi)-Based Nanomaterials for Cancer Imaging and Therapy: A Materials Perspective

ACS Nano. 2021 Jan 23. doi: 10.1021/acsnano.0c07899.

Yu X, Liu X, Yang K, Chen X, Li W.


A hybrid semiconducting organosilica-based O2 nanoeconomizer for on-demand synergistic photothermally boosted radiotherapy

Nat Commun. 2021;12(1):523.

Tang W, Yang Z, He L, Deng L, Fathi P, Zhu S, Li L, Shen B, Wang Z, Jacobson O, Song J, Zou J, Hu P, Wang M, Mu J, Cheng Y, Ma Y, Tang L, Fan W, Chen X


177Lu-DOTA-EB-TATE, a Radiolabeled Analogue of Somatostatin Receptor Type 2, for the Imaging and Treatment of Thyroid Cancer

Clin Cancer Res. 2020 Dec 22. doi: 10.1158/1078-0432.CCR-20-3453.

Thakur S, Daley B, Millo C, Cochran C, Jacobson O, Lu H, Wang Z, Kiesewetter D, Chen X, Vasko V, Klubo-Gwiezdzinska J.


Stimuli-Responsive Plasmonic Assemblies and Their Biomedical Applications.

Nano Today. 2021;36:101014.

Fu Q, Li Z, Fu F, Chen X, Song J, Yang H.


Imaging of Insulinoma by Targeting Glucagonlike Peptide-1 Receptor.

PET Clin. 2021 Feb 12:S1556-8598(20)30103-6.

Luo Y, Chen X

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