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Publications in 2020


Resection and survival data from a clinical trial of glioblastoma multiforme-specific IRDye800-BBN fluorescence-guided surgery.

Bioeng Transl Med. 2020;6(1):e10182.

He K, Chi C, Li D, Zhang J, Niu G, Lv F, Wang J, Che W, Zhang L, Ji N, Zhu Z, Tian J, Chen X.


Supramolecular coordination complexes as diagnostic and therapeutic agents.

Curr Opin Chem Biol. 2020;61:19-31.

Yu G, Jiang M, Huang F, Chen X


Reactive Oxygen Species Activatable Heterodimeric Prodrug as Tumor-Selective Nanotheranostics.

ACS Nano. 2020; 14: 16875–16886

Jiang M, Mu J, Jacobson O, Wang Z, He L, Zhang F, Yang W, Lin Q, Zhou Z, Ma Y, Lin J, Qu J, Huang P, Chen X


First report of 68Ga-PRGD2 PET/MRI molecular imaging of vaso-occlusion in a patient with sickle cell disease.

BJR Case Rep. 2020;6(4):20200024.

Novelli EM, Moon CH, Pham TA, Perkins LA, Little-Ihrig L, Tavakoli S, Mason NS, Lang L, Chen X, Laymon CM, Gladwin MT, Anderson CJ.


Genetically engineered magnetic nanocages for cancer magneto-catalytic theranostics

Nat Commun. 2020;11(1):5421.

Zhang Y, Wang X, Chu C, Zhou Z, Chen B, Pang X, Lin G, Lin H, Guo Y, Ren E, Lv P, Shi Y, Zheng Q, Yan X, Chen X, Liu G.


Size-Transformable Antigen-Presenting Cell Mimicking Nanovesicles for Effective Cancer Immunotherapy

Sci Adv, 2020;6(50):eabd1631.

Yang W, Deng H, Zhu S, Lau J, Tian R, Wang S, Zhou Z, Yu G, Rao L, He L, Ma Y, Chen X


Targeted Scavenging of Extracellular ROS Relieves Suppressive Immunogenic Cell Death

Nat Commun, 2020;11(1):4951.

Deng H, Yang W, Zhou Z, Tian R, Lin L, Ma Y, Song J, Chen X


New Opportunities in Cancer Immunotherapy and Theranostics.

Acc Chem Res. 2020;53(12):2763-2764.

Chen XS, Moon JJ, Cheon J.


Cascade Drug Release Strategy for Enhanced Anticancer Therapy

Matter, 2021; 4: 26-53 

Zhang X, Wang S, Cheng G, Yu P, Chang J, Chen X


Activating Macrophage-Mediated Cancer Immunotherapy by Genetically Edited Nanoparticles

Adv Mater, 2020;32:2004853

Rao L, Zhao S-K, Wen C, Tian R, Lin L, Cai B, Sun Y, Kang F, Yang Z, He L, Mu J, Meng Q-F, Yao G, Xie N, Chen X


Decoy nanoparticles protect against COVID-19 by concurrently adsorbing viruses and inflammatory cytokines

PNAS, 2020:202014352. [cover story, highlighted by the Scientist]

Rao L, Xia S, Xu W, Tian R, Yu G, Gu C, Pan P, Meng Q-F, Cai X, Qu D, Lu L, Xie Y, Jiang S, Chen X


Reducing false negatives in COVID-19 testing by using microneedle-based oropharyngeal swabs

Matter, 2020;3(5):1589-1600. [Cover]

Chen W, Cai B, Cheng Z, Chen F, Wang Z, Wang L, Chen X


Peptide Receptor Radionuclide Therapy of Late-stage Neuroendocrine Tumor Patients with Multiple Cycles of 177Lu-DOTA-EB-TATE

J Nucl Med. 2020 Aug 21:jnumed.120.248658. doi: 10.2967/jnumed.120.248658.

Liu Q, Zang J, Sui H, Ren J, Guo H, Wang H, Wang R, Jacobson O, Zhang J, Cheng Y, Zhu Z, Chen X.


Targeted radionuclide therapy in patient-derived xenografts using 177Lu-EB-RGD

Mol Cancer Ther. 2020; 19(10): 2034-2043. 

Zhao L, Chen H, Guo Z, Fu K, Yao L, Fu L, Guo W, Wen X, Jacobson O, Zhang X, Sun L, Wu H, Lin Q, Chen X.


Recent Advances in Stimuli-Responsive Platforms for Cancer Immunotherapy

Acc Chem Res. 2020; 53(10): 2044-2054.

Li L, Yang Z, Chen X.


Cell Death Mediated by Pyroptosis Pathway with the Help of Nanotechnology: New Prospects for Cancer Therapy

Angew Chem Int Ed Engl. 2020 Sep 7. doi: 10.1002/anie.202010281.

Wu D, Wang S, Yu G, Chen X.


The critical size of gold nanoparticles for overcoming P-gp mediated multidrug resistance

Nanoscale. 2020;12(31):16451-16461.

Jiang Y, Wang Z, Duan W, Liu L, Si M, Chen X, Fang CJ


Endogenous Labile Iron Pool-Mediated Free Radical Generation for Cancer Chemodynamic Therapy

J Am Chem Soc. 2020; 142(36): 15320-15330.

Lin L, Wang S, Deng H, Yang W, Rao L, Tian R, Liu Y, Yu G, Zhou Z, Song J, Yang HH, Chen ZY, Chen X


Designer cell membrane nanovesicles amplify macrophage immune responses against cancer recurrence and metastasis

Nat Commun, 2020;11(1):4909.

Rao L, Wu L, Liu Z, Tian R, Yu G, Zhou Z, Yang K, Xiong HG, Zhang A, Yu GT, Li A, Chen H, Sun ZJ, Fu YX, Chen X


Nanoparticle delivery in vivo: a fresh look from an intravital imaging perspective

EBioMedicine, 2020;59:102958

Lin Q, Fathi P, Chen X


Cascade Reactions Catalyzed by Planar Metal Organic Framework Hybrid Architecture for Combined Cancer Therapy

Small, 2020;e2004016.

Mu J, He L, Fan W, Tang W, Wang Z, Jiang C, Zhang D, Liu Y, Deng H, Zou J, Jacobson O, Qu J, Huang P, Chen X


Multimodal Photoacoustic Imaging-Guided Regression of Corneal Neovascularization: A Non-Invasive and Safe Strategy

Adv Sci (Weinh). 2020;7(14):2000346. doi: 10.1002/advs.202000346.

Chu C, Yu J, Ren E, Ou S, Zhang Y, Wu Y, Wu H, Zhang Y, Zhu J, Dai Q, Wang X, Zhao Q, Li W, Liu Z, Chen X, Liu G


Theranostic multimodal gold nanoclusters

Nat Biomed Eng. 2020;4(7):668-669.

He G, Huang P, Chen X


Targeting Neutrophils for Enhanced Cancer Theranostics

Adv Mater, 2020; 32: 2002739

Tang L, Wang Z, Mu Q, Yu Z, Jacobson O, Li L, Yang W, Huang C, Kang F, Fan W, Ma Y, Wang S, Zhou Z, Chen X


Advanced biomimetic nanoreactor for specifically killing tumor cells through multi-enzyme cascade

Theranostics. 2020;10(14):6245-6260.

Liu W, Wu J, Ji X, Ma Y, Liu L, Zong X, Yang H, Dai J, Chen X, Xue W


Zwitterionic-to-cationic charge conversion polyprodrug nanomedicine for enhanced drug delivery

Theranostics. 2020;10(15):6629-6637.

Wang S, Zhang F, Yu G, Wang Z, Jacobson O, Ma Y, Tian R, Deng H, Yang W, Chen ZY, Chen X


Dancing with reactive oxygen species generation and elimination in nanotheranostics for disease treatment

Adv Drug Deliv Rev. 2020; 158: 73-90.

Zhou Z, Ni K, Deng H, Chen X


Critical reviews of immunotheranostics

Theranostics. 2020;10(16):7403-7405.

Chen X, Chen M.


Tuning the properties of atomically precise gold nanoclusters for biolabeling and drug delivery

Chem Commun (Camb). 2020; 56(62): 8766-8769.

Xu MM, Jia TT, Li B, Ma W, Chen X, Zhao X, Zang SQ


Engineering macrophages for cancer immunotherapy and drug delivery

Adv Mater, 2020;32(40):e2002054.

Xia Y, Rao L, Yao H, Wang Z, Ning P, Chen X


Controllable Synthesis of Versatile Mesoporous Organosilica Nanoparticles as Precision Cancer Theranostics

Biomaterials, 2020;256:120191

Cheng Y, Jiao X, Fan W, Yang Z, Wen Y, Chen X


Insight into the Development of PET Radiopharmaceuticals for Oncology

Cancers, 2020;12(5):1312 

Lau J, Rousseau E, Kwon D, Lin K-S, Bernard F, Chen X


Ultrasmall Copper-Based Nanoparticles for Reactive Oxygen Species Scavenging and Alleviation of Inflammation Related Diseases

Nat Commun, 2020;11(1):2788 

Liu T, Xiao B, Xiang F, Tan J, Chen Z, Wu C, Mao Z, Luo G, Chen X, Deng J


A single-step multi-level supramolecular system for cancer sonotheranostics

Nanoscale Horiz. 2019;4(1):190-195.

Lin H, Li S, Wang J, Chu C, Zhang Y, Pang X, Lv P, Wang X, Zhao Q, Chen J, Chen H, Liu W, Chen X, Liu G


Quantum Dot-Based Sensitization System for Boosted Photon Absorption and Enhanced Second Near-Infrared Luminescence of Lanthanide-Doped Nanoparticle

Anal Chem, 2020; 92(8): 6094-6102.

Zhang W, Chen T, Su L, Ge X, Chen X, Song J, Yang H


Early stratification of radiotherapy response by activatable inflammation magnetic resonance imaging

Nat Commun, 2020;11(1):3032   

Zhou Z, Deng H, Yang W, Wang Z, Lin L, Munasinghe J, Jacobson O, Liu Y, Tang L, Ni Q, Kang F, Liu Y, Niu G, Bai R, Qian C, Song J, Chen X


177Lu-EB-PSMA radioligand therapy with escalating doses in patients with metastatic castration-resistant prostate cancer

J Nucl Med, 2020; 61(12):1772-1778.

Zang J, Liu Q, Sui H, Wang R, Jacobson O, Fan X, Zhu Z, Chen X


Gadolinium-Rose Bengal Coordinated Polymer Nanodots for MR/Fluorescence ImageGuided Radiation and Photodynamic Therapy

Adv Mater, 2020;32(23):e2000377.

Sun W, Luo L, Feng Y, Qiu Y, Meng S, Chen X, Chen H


Biologically Responsive Plasmonic Assemblies for Second Near-Infrared Window Photoacoustic Imaging-Guided Concurrent Chem-Immunotherapy

ACS Nano, 2020; 14(4): 3991-4006.

Zhu R, Su L, Dai J, Li ZW, Bai S, Li Q, Chen X, Song J, Yang H 


 [18F]- Alfatide PET imaging of integrin αvβ3 for the non-invasive quantification of liver fibrosis

J Hepatol. 2020;73(1):161-169.

Shao T, Chen Z, Belov V, Wang X, Rwema SH, Kumar V, Fu H, Deng X, Rong J, Yu Q, Lang L, Lin W, Josephson L, Samir AE, Chen X, Chung RT, Liang SH.


Yolk-shell nanovesicles endow glutathione-responsive concurrent drug release and T1 MRI activation for cancer theranostics

Biomaterials, 2020; 244: 119979

Liu D, Zhou Z, Wang X, Deng H, Kang F, Zhang Y, Wang Z, Yang W, Rao L, Yang K, Yu G, Du J, Shen Z, Chen X


Stereospecific Interactions between Chiral Nanomaterials and Biological Systems

Chem Soc Rev, 2020; 49: 2481-2503

Zhao X, Zang S, Chen X


Solvent-assisted self-assembly of metal-organic framework-based biocatalyst for cascade reactions-driven photodynamic therapy

J Am Chem Soc, 2020; 142(14): 6822-6832.

He L, Ni Q, Mu J, Fan W, Liu L, Wang Z, Li L, Tang W, Liu Y, Cheng Y, Tang L, Yang Z, Liu Y, Zou J, Yang W, Jacobson O, Zhang F, Huang P, Chen X


X-ray-Induced Persistent Luminescence Promotes Ultrasensitive Imaging and Effective Inhibition of Orthotopic Hepatic Tumors

Adv Funct Mater, 2020, 2001166   

Shi T, Sun W, Qin R, Li D, Feng Y, Chen L, Liu G, Chen X, Chen H


Targeting Integrins with Radiolabeled RGD Analogs for Radiotheranostics of Metastatic Radioactive Iodine Non-Responsive Thyroid Cancer - New Avenues in Personalized Medicine

Thyroid. 2020; 30(4): 476-478.

Klubo-Gwiezdzinska J, Chen X.


Photoacoustic Imaging-Trackable Magnetic Microswimmers for Pathogenic Bacterial Infection Treatment

ACS Nano, 2020; 14(3): 2880-2893.

Xie L, Pang X, Yan X, Lin H, Ye J, Cheng Y, Dai Q, Zhao Q, Zhang X, Liu G, Chen X


Cell Membrane Mimicking Nanodecoys Against Infectious Diseases

ACS Nano, 2020; 14(3): 2569-2574.

Rao L, Tian R, Chen X


Conjugation of a Scintillator Complex and Gold Nanorods for Dual-Modal Image-Guided Photothermal and X-RayInduced Photodynamic Therapy of Tumors

ACS Appl Mater Interfaces, 2020; 12(11): 12591-12599.

Luo L, Sun W, Feng Y, Qin R, Zhang J, Ding D, Shi T, Liu X, Chen X, Chen H


Endoplasmic Reticulum Targeting to Amplify Immunogenic Cell Death for Cancer Immunotherapy

Nano Lett, 2020; 20(3): 1928-1933.

Deng H, Zhou Z, Yang W, Lin L-S, Wang S, Niu G, Song J, Chen X


A Fluorinated-Ionic-Liquid-Based Activatable 19F MRI Platform Enables Detection and Imaging of Biological Targets

Chem, 2020;6:1134-1148.

Zhu X, Tang X, Lin H, Shi S, Xiong H, Zhou Q, Li A, Wang Q, Chen X, Gao J


Lymphangioleiomyomatosis revealed by 68Ga-NOTA-Evans Blue PET/CT

Eur J Nucl Med Mol Imaging. 2020; 47(10): 2469-2470.

Hou G, Xu W, Jiang Y, Xu KF, Chen X, Li F, Cheng W


Small-sized gadolinium oxide based nanoparticles for high-efficiency theranostics of orthotopic glioblastoma

Biomaterials. 2020;235:119783

Shen Z, Liu T, Yang Z, Zhou Z, Tang W, Fan W, Liu Y, Mu J, Li L, Bregadze VI, Mandal SK, Druzina AA, Wei Z, Qiu X, Wu A, Chen X


A phototheranostics strategy to continuously deliver singlet oxygen in dark and hypoxic tumor microenvironment

Angew Chem Int Ed Engl. 2020; 59: 1-7.

Zou J, Zhu J, Yang Z, Li L, Fan W, He L, Tang W, Deng L, Mu J, Ma Y, Cheng Y, Huang W, Dong X, Chen X


Ultrasound Activated Sensitizers and Applications

Angew Chem Int Ed Engl. 2020; 59: 2-24

Lin X, Song J, Chen X, Yang H.


Current clinical status and potential of photothermal and photodynamic cancer therapy

Nat Rev Clin Oncol, 2020; 17(11): 657-674.

Li X, Lovell J, Yoon J, Chen X


Burst release of encapsulated annexin A5 in tumours boosts cytotoxic T-cell responses by blocking the phagocytosis of apoptotic cells

Nat Biomed Eng, 2020; 4: 1102-1116.

Li L, Zou J, Dai Y, Fan W, Niu G, Yang Z, Chen X


Multiplexed NIR-II imaging for lymph node-invaded cancer detection and full-process light exposure surgery

Adv Mater, 2020;32:1907365 

Tian R, Ma H, Zhu S, Lau J, Ma R, Liu Y, Lin L, Chandra S, Wang S, Niu G, Zhang M, Antaris AL, Hettie KS, Yang B, Liang Y, Chen X


Oxidative stress-driven DR5 upregulation restores TRAIL/Apo2L sensitivity induced by iron oxide nanoparticles in colorectal cancer

Biomaterials, 2020;233:119753

Shi Y, Wang J, Liu J, Lin G, Xie F, Pang X, Pei Y, Cheng Y, Zhang Y, Lin Z, Yin Z, Wang X, Niu G, Chen X, Liu G


Cascaded Multiresponsive Self-Assembled 19F MRI Nanoprobes with Redox-Triggered Activation and NIR-Induced Amplification

Nano Lett, 2020;20(1):363-371

Tang X, Gong X, Li A, Lin H, Peng C, Zhang X, Chen X, Gao J.


Combined 68Ga-NOTA-Evans Blue Lymphoscintigraphy and 68Ga-NOTA-RM26 PET/CT Evaluation of Sentinel Lymph Node Metastasis in Breast Cancer Patients

Bioconjug Chem, 2020; 31(2):396-403.

Zang J, Liu Q, Sui H, Guo H, Peng L, Li F, Lang L, Jacobson O, Mao F, Zhu Z, Chen X


Smart Nanovesicle Mediated Immunogenic Cell Death Through Tumor Microenvironment Modulation for Effective Photodynamic-Immunotherapy

ACS Nano, 2020;14(1):620-631

Yang W, Zhang F, Deng H, Lin L, Wang S, Kang F, Yu G, Lau J, Tian R, Zhang M, Wang Z, He L, Ma Y, Niu G, Hu S, Chen X


Label-free Visualization of Early Cancer Hepatic Micrometastasis and Intraoperative Image-guided Surgery by Photoacoustic Imaging

J Nucl Med. 2020;61(7):1079-1085.

Yu Q, Huang S, Wu Z, Zheng J, Chen X, Nie L.


A bi-adjuvant nanovaccine that potentiates immunogenicity of neoantigen for combination immunotherapy of colorectal cancer

Sci Adv, 2020;6:eaaw6071

Ni Q, Zhang F, Liu Y, Wang Z, Yu G, Liang B, Niu G, Su T, Lu G, Zhu G, Zhang L, Chen X


Ultrasound Activated Vesicle of Janus Au-MnO Nanoparticles for Promoted Tumor Penetration and Sono-Chemodynamic Therapy of Orthotopic Liver Cancer

Angew Chem Int Ed Engl. 2020;59(4):1682-1688.

Lin X, Liu S, Zhang X, Zhu R, Chen S, Chen X, Song J, Yang H.


Nanoscintillator-mediated X-ray induced photodynamic therapy for deep-seated tumors: from concept to biomedical applications 

Theranostics, 2020;10(3):1296-1318.

Sun W, Zhou Z, Pratx G, Chen X, Chen H


Core–Shell Heterostructured Magnetic–Plasmonic Nanoassemblies with Highly Retained Magnetic–Plasmonic Activities for Ultrasensitive Bioanalysis in Complex Matrix 

Adv Sci, 2020;7:1902433

Hao L, Leng Y, Zeng L, Chen X, Chen J, Duan H, Huang X, Xiong Y, Chen X


Supramolecular Recognition-Mediated Layer-by-Layer Self-Assembled Gold Nanoparticles for Customized Sensitivity in Paper-Based Strip Nanobiosensors

Small. 2019;15(51):1903861.

Huang X, Zhou Y, Ding L, Yu G, Leng Y, Lai W, Xiong Y, Chen X


DOTA-Branched Organic Frameworks as Giant and Potent Metal Chelators

J Am Chem Soc. 2020;142(1):198-206.

Sun C, Lin H, Gong X, Yang Z, Mo Y, Chen X, Gao J.


Tale of Two Magnets: A New Design of Magnetic Targeting System

ACS Nano, 2020;14(1):7-11

Zhou Z, Shen Z, Chen X


Dose Escalation of an Evans Blue Modified Radiolabeled Somatostatin Analogue 177Lu-DOTA-EBTATE in the Treatment of Metastatic Neuroendocrine Tumors

Eur J Nucl Med Mol Imaging. 2020;47(4):947-957

Liu Q, Cheng Y, Zang J, Sui Hm Wang H, Jacobson O, Zhu Z, Chen X

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