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Publications in 2017


Functional ferritin nanoparticles for biomedical applications

Front Chem Sci Eng, 2017;11(4):633-646. 

Wang Z, Gao H, Zhang Y, Liu G, Niu G, Chen X


Supramolecular Nanomedicine Constructed from Cucurbit[8]uril-Based Amphiphilic Brush Copolymer for Cancer Therapy

ACS Appl Mater Interf, 2017;9 (51):44392–44401

Wu D, Li Y, Yang J, Shen J, Zhou J, Zhao R, Hu Q, Yu G, Tang G, Chen X


Reprogrammable ultra-fast shape-transformation of macroporous composite hydrogel sheets

J Mater Chem B Mater Biol Med. 2017;5(16):2883-2887.

Guo H, Cheng J, Wang J, Huang P, Liu Y, Jia Z, Chen X, Sui K, Li T, Nie Z.


Design and development of multifunctional polyphosphoester-based nanoparticles for ultrahigh paclitaxel dual loading

Nanoscale. 2017;9(41):15773-15777.

Zhang F, Khan S, Li R, Smolen JA, Zhang S, Zhu G, Su L, Jahnke AA, Elsabahy M, Chen X, Wooley KL


Albumin/Vaccine Nanocomplexes That Assemble In Vivo for Combination Cancer Immunotherapy 

Nat Comm, 2017;8:1954.  

Zhu G, Lynn GM, Jacobson O, Chen K, Liu Y, Zhang H, Ma Y, Zhang F, Tian R, Ni Q, Cheng S, Wang Z, Lu N, Yung BC, Wang Z, Lang L, Fu X, Jin A, Weiss ID, Vishwasrao H, Niu G, Shroff H, Klinman DM, Seder RA, Chen X


Antitumor Activity of a Unique Polymer That Incorporates a Fluorescent Self-Assembled Metallacycle

J Am Chem Soc, 2017;139(44):15940-15949.

Yu G, Zhang M, Saha ML, Mao Z, Chen J, Yao Y, Zhou Z, Liu Y, Gao C, Chen X, Stang PJ


Inhibiting Metastasis and Preventing Tumor Relapse by Triggering Host Immunity with Tumor-Targeted Photodynamic Therapy Using Photosensitizer-Loaded Functional Nanographenes

ACS Nano. 2017;11(10):10147-10158.

Yu X, Gao D, Gao L, Lai J, Zhang C, Zhao Y, Zhong L, Jia B, Wang F, Chen X, Liu Z.


2D Gold Nanorings Enhance Tumor Uptake and Suppress Nanoparticle-Mononuclear Phagocyte System Interaction

ACS Nano, 2017;11(10):10539-10548.

Liu Y, Wang Z, Liu Y, Zhu G, Weiss OJ, Fu X, Bai R, Lin X, Lu N, Yang X, Fan W, Song J, Wang Z, Yu G, Zhang F, Kalish H, Niu G, Nie Z, Chen X


Ceria nanocrystals decorated mesoporous silica nanoparticle based ROS-scavenging tissue adhesive for highly efficient regenerative wound healing

Biomaterials, 2017;151:66-77.

Wu H, Li F, Wang S, Lu J, Li J, Du Y, Sun X, Chen X, Gao J, Ling D


Intertwining DNA-RNA nanocapsules loaded with tumor neoantigens as synergistic nanovaccines for personalized cancer immunotherapy

Nat Comm, 2017;8:1482.

Zhu G, Mei L, Vishwasrao HD, Jacobson O, Wang Z, Liu Y, Yung BC, Fu X, Jin A, Niu G, Wang Q, Zhang F, Shroff H, Chen X


Microneedle-array patches loaded with dual mineralized protein/peptide particles for type 2 diabetes therapy

Nat Comm, 2017;8:1777.

Chen W, Tian R, Xu C, Yung BC, Wang G, Liu Y, Zhang F, Zhou Z, Fu L, Chen X


Engineered Zn(II)-Dipicolylamine-Gold Nanorod Provides Effective Prostate Cancer Treatment by Combining siRNA Delivery and Photothermal Therapy

Theranostics, 2017;7(17):4240-4254.

Min KH, Kim Y-H, Wang Z, Kim J, Kim JS, Kim SH, Kim K, Kwon IC, Kiesewetter DO, Chen X


Black hollow silicon oxide nanoparticles as highly efficient photothermal agents in the second near-infrared window for in vivo cancer therapy

Biomaterials. 2017;143:120-129.

Yu X, Yang K, Chen X, Li W


Multifunctional Theranostic Nanoparticles Based on Exceedingly Small Magnetic Iron Oxide Nanoparticles for T1-Weighted Magnetic Resonance Imaging and Chemotherapy 

ACS Nano, 2017;11(11):10992-11004.

Shen Z, Chen T, Ma X, Ren W, Zhou Z, Zhu G, Liu Y, Song J, Li Z, Ruan H, Fan W, Lin L, Munasinghe J, Chen X, Wu A


Transformative Nanomedicine of an Amphiphilic Camptothecin Prodrug for Long Circulation and High Tumor Uptake in Cancer Therapy

ACS Nano, 2017;11(9):8838-8848.

Zhang F, Zhu G, Jacobson O, Liu Y, Chen K, Yu G, Ni Q, Fan J, Yang Z, Xu F, Fu X, Wang Z, Ma Y, Niu G, Zhao X, Chen X


Nanotechnology for multimodal synergistic cancer therapy 

Chem Rev, 2017;117(22):13566-13638.

Fan W, Yung B, Huang P, Chen X


Chemotherapeutic drug-photothermal agent co-self-assembling nanoparticles for near-infrared fluorescence and photoacoustic dual-modal imaging-guided chemo-photothermal synergistic therapy

J Control Release. 2017;258:95-107.

Li Y, Liu G, Ma J, Lin J, Lin H, Su G, Chen D, Ye S, Chen X, Zhu X, Hou Z.


Emerging advances in nanotheranostics with intelligent bioresponsive systems 

Theranostics, 2017; 7(16):3915-3919.

Wang J, Tao W, Chen X, Farokhzad OC, Liu G


Improved Tumor Targeting and Longer Retention Time of NIR Fluorescent Probes Using Bioorthogonal Chemistry 

Theranostics, 2017; 7(15):3794-3802.

Zhang X, Wang B, Zhao N, Tian Z, Dai Y, Nie Y, Tian J, Wang Z, Chen X


Peptides and Peptide Conjugates in Medicine.

Adv Drug Deliv Rev. 2017 Feb;110-111:1-2.

Cui H, Chen X


T1-T2 Dual-Modal Magnetic Resonance Imaging: From Molecular Basis to Contrast Agents

ACS Nano, 2017;11(6):5227-5232.

Zhou Z, Bai R, Munasinghe J, Shen Z, Nie L, Chen X


Protein Nanocages that Penetrate Airway Mucus and Tumor Tissue

PNAS, 2017;114(32):E6595-E6602.

Huang X, Chisholm J, Zhuang J, Xiao Y, Duncan G, Chen X, Suk JS, Hanes J


Rational Design of Branched Nanoporous Gold Nanoshells with Enhanced Physico-optical Properties for Optical Imaging and Cancer Therapy

ACS Nano, 2017;11(6):6102-6113.  

Song J, Yang X, Yang Z, Lin L, Liu Y, Zhou Z, Shen Z, Yu G, Dai Y, Jacobson O, Munasinghe J, Teng G, Chen X


Core-Satellite Polydopamine-Gadolinium Metallofullerene Nanotheranostics for Multimodal Imaging Guided Synergistic Cancer Therapy

Adv Mater, 2017; 29:1701013 

Wang S, Lin J, Wang Z, Zhou Z, Bai R, Lu N, Liu Y, Fu X, Jacobson O, Fan W, Qu J, Chen S, Wang T, Huang P, Chen X 


Double-Layered Plasmonic-Magnetic Vesicles by Self-Assembly of Janus Amphiphilic Au–Fe3O4 Nanoparticles

Angew Chem Int Ed Engl, 2017; 56:8110 –8114

Song J, Wu B, Zhou Z, Zhu G, Liu Y, Yang Z, Lin L, Yu G, Zhang F, Zhang G, Duan H, Stucky GD, Chen X


Nanotechnology-Enhanced No-Wash Biosensors for In Vitro Diagnostics of Cancer

ACS Nano, 2017;11(6):5238-5292.

Huang X, Liu Y, Yung B, Xiong Y, Chen X


Ultrasound-Mediated Diagnosis and Therapy

Small Methods, 2017;1:1700173

Yoon YI, Tang W, Chen X


Enhanced Afterglow Performance of Persistent Luminescence Implants for Efficient Repeatable Photodynamic Therapy

ACS Nano, 2017;11(6):5864-5872.  

Fan W, Lu N, Xu C, Liu Y, Lin J, Wang S, Shen Z, Yang Z, Qu J, Wang T, Chen S, Huang P, Chen X


Molecular Imaging of Acute Cardiac Transplant Rejection: Animal Experiments and Prospects

Transplantation, 2017;101(9):1977-1986.

Chen Y, Zhang L, LJ, Zhang P, Chen X, Xie M


Multifunctional Molecular Beacon Micells for Intracellular mRNA Imaging and Synergistic Therapy in Multidrug-Resistant Cancer Cells

Adv Funct Mater, 2017;27:1701027 (Front Cover)

Zhang R, Gao S, Wang Z, Han D, Liu L, Ma Q, Tan W, Tian J, Chen X


PET-guided evaluation and optimization of internalized antibody-drug conjugates targeting erythropoietin producing hepatoma A2 receptor

J Nucl Med, 2017;58(11):1838-1844.

Jaobson O, Chen H, Niu G, Kiesewetter DO, Li Q, Yang G, Xu L, Dall’Acqua W, Tsui P, Peng L, Chen X


Quantification of Tumor Vascular Permeability and Blood Volume by Positron Emission Tomography 

Theranostics, 2017; 7(9):2363-2376.

Chen H, Tong X, Lang L, Jacobson O, Yung BC, Yang X, Bai R, Kiesewetter DO, Ma Y, Wu H, Niu G, Chen X


Long-acting release formulation of exendin-4 based on biomimetic mineralization for type 2 diabetes therapy

ACS Nano, 2017; 11(5):5062-5069.

Chen W, Wang G, Yung BC, Qian Z, Chen X


Nanoparticle design strategies for enhanced anticancer therapy by exploiting tumour microenvironment

Chem Soc Rev, 2017;46(12):3830-3852.

Dai Y, Sun X, Chen X


Self-Assembly of Semiconducting-Plasmonic Gold Nanoparticles with Enhanced Optical Property for Photoacoustic Imaging and Photothermal Therapy

Theranostics, 2017;7(8):2177-2185.

Yang Z, Song J, Chen J, Wang F, Lin L, Liu Y, Zhang F, Yu G, Zhou Z, Fan W, Huang W, Fan Q, Chen X


Biocompatible D–A Semiconducting Polymer Nanoparticle with Light-Harvesting Unit for Highly Effective Photoacoustic Imaging Guided Photothermal Therapy

Adv Funct Mater, 2017;27:1605094 (Inside Back Cover)

Zhang J, Yang C, Zhang R, Chen R, Zhang Z, Zhang W, Peng S-H, Chen X, Liu G, Hsu C-S, Lee C-S


Ultra-small Semimetal Nanoparticles of Bismuth for Dual-Modal CT/Photoacoustic Imaging and Synergistic Thermoradiotherapy

ACS Nano, 2017; 11(4):3990-4001.

Yu X, Li A, Zhao C, Yang K, Chen X, Li W


Activatable Singlet Oxygen Generation from Lipid Hydroperoxide Nanoparticles for Cancer Therapy

Angew Chem Int Ed Engl, 2017;56(23):6492-6496.

Zhou Z, Song J, Tian R, Yang Z, Yu G, Lin L, Zhang G, Fan W, Zhang F, Niu G, Nie L, Chen X


Impact of Semiconducting Perylene Diimide Nanoparticle Size on Lymph Node Mapping and Cancer Imaging

ACS Nano, 2017;11(4):4247-4255.

Yang Z, Tian R, Wu J, Fan Q, Yung BC, Niu G, Jacobson O, Wang Z, Liu G, Yu G, Huang W, Song J, Chen X


Tumor microenvironment-triggered supramolecular system as in situ nanotheranostic generator for enhanced cancer phototherapy

Adv Mater, 2017;29:1605928. 

Chu C, Lin H, Liu H, Wang X, Wang J, Zhang P, Gao H, Huang C, Zeng Y, Tan Y, Liu G, Chen X


Rethinking Cancer Nanotheranostics

Nat Rev Mater, 2017;2:17024

Chen H, Zhang W, Zhu G, Xie J, Chen X


Yolk-Shell Nanostructure: An Ideal Architecture to Achieve Harmonious Integration of Magnetic-Plasmonic Hybrid Theranostic Platform

Adv Mater. 2017;29:1606681

Lin LS, Yang X, Zhou Z, Yang Z, Jacobson O, Liu Y, Yang A, Niu G, Song J, Yang HH, Chen X


Croconaine nanoparticles with enhanced tumor accumulation for multimodality cancer theranostics

Biomaterials. 2017;129:28-36.

Tang L, Zhang F, Yu F, Sun W, Song M, Chen X, Zhang X, Sun X


Reprogrammable ultra-fast shape-transformation of macroporous composited hydrogel sheets

J Mater Chem B, 2017;5:2883-2887.

Guo H, Cheng J, Wang J, Huang P, Liu Y, Jia Z, Chen X, Sui K, Li T, Nie Z


Recent Advances in High-Performance fluorescent and bioluminescent RNA Imaging Probes 

Chem Soc Rev, 2017;46;2824-2843.

Xia Y, Zhang R, Wang Z, Tian J, Chen X


Current Detection Technologies of Circulating Tumor Cells

Chem Soc Rev, 2017;46:2038-2056 (Inside Front Cover)

Shen Z, Wu A, Chen X


Efficient Nanovaccine Delivery in Cancer Immunotherapy

ACS Nano. 2017;11(3):2387-2392.

Zhu G, Zhang F, Ni Q, Niu G, Chen X


Artificial local magnetic field inhomogeneity enhances T2 relaxivity

Nat Comm, 2017;8: 15468

Zhou Z, Tian R, Wang Z, Yang Z, Liu Y, Liu G, Wang R, Gao J, Song J, Nie L, Chen X


Tri-Stimuli-Responsive Biodegradable Theranostics for Mild Hyperthermia Enhanced Chemotherapy

Biomaterials, 2017;126:39-48. 

Lu N, Huang P, Fan W, Wang Z, Liu Y, Wang S, Zhang G, Hu J, Niu G, Leapman RD, Lu G, Chen X


Cancer-Associated, Stimuli-Driven, Turn on Theranostics for Multimodal Imaging Guided Therapy

Adv Mater, 2017;29:1606857

Li X, Kim J, Yoon J, Chen X


Diverse Applications of Nanomedicine

ACS Nano, 2017;11(3):2313-2381.

Pelaz B, …Chen X, …Parak WJ


An Ultrasensitive Biosensing Platform Employing Acetylcholinesterase and Gold Nanoparticles

Methods Mol Biol, 2017;1530:307-316.

Liu D, Chen X.


Combinatory screening of DNA aptamers for molecular imaging of HER2 in cancer 

Bioconjugate Chem, 2017;28:1068-1075. 

Zhu G, Zhang H, Jacobson O, Wang Z, Chen H, Yang X, Niu G, Chen X


Degradable Hollow Mesoporous Silicon/Carbon Nanoparticles for Photoacoustic Imaging-Guided Highly Effective Chemo-Thermal Tumor Therapy in Vitro and in Vivo 

Theranostics, 2017; 7(12):3007-3020.

Zhang J, Zhang J, Li W, Chen R, Zhang Z, Zhang W, Tang Y, Chen X, Liu G, Lee CS


Development of sialic acid-coated nanoparticles for targeting cancer and efficient evasion of the immune system

Theranostics, 2017;7(4):962-973. 

Kim Y-H, Min KH, Wang Z, Kim J, Jacobson O, Huang P, Zhu G, Liu Y, Yung B, Niu G, Chen X


TAT-modified gold nanoparticle carrier with enhanced anticancer activity and size effect on overcoming multidrug resistance

ACS Appl Mater Interfaces, 2017;9(7):5828-5837.

Wang RH, Bai J, Deng J, Fang CJ, Chen X


Ratiometric Photoacoustic Molecular Imaging for Methylmercury Detection in Living Subjects

Adv Mater, 2017 Feb 22. doi: 10.1002/adma.201606129.

Liu Y, Wang S, Ma Y, Lin J, Wang HY, Gu Y, Chen X, Huang P


Engineering phototheranostic nanoscale metal-organic frameworks for multi-modal imaging-guided cancer therapy

ACS Appl Mater Interfaces, 2017; 9(3): 2040-2051.

Cai W, Gao H, Chu C, Wang X, Wang J, Zhang P, Lin G, Liu G, Chen X


Highly Specific C-C Bond Cleavage Induced FRET Fluorescence for in vivo Biological Nitric Oxide Imaging 

Chem Sci, 2017; 8: 2199-2203

Li H, Zhang D, Gao M, Huang L, Tang L, Li Z, Chen X, Zhang X


Glucose-Responsive Sequential Generation of H2O2 and NO for Synergistic Cancer Starving-Like/Gas Therapy

Angew Chem Int Ed Engl, 2017;56(5):1229-1233. (Back cover)

Fan W, Lu N, Huang P, Liu Y, Yang Z, Wang S, Yu G, Liu Y, Hu J, He Q, Qu J, Wang T, Chen X


Improved Tumor Uptake by Optimizing Liposome Based RES Blockade Strategy 

Theranostics, 2017; 7(2): 319-328.

Wang Z, Yan X, Sun X, Jacobson O, Sun W, Tong X, Xia Y, Ling D, Chen X


Amphiphilic Polymer-Guided Plasmonic Assemblies and Their Biomedical Applications

Bioconjugate Chem, 2017; 28(1): 105–114

Song J, Niu G, Chen X


Iron Oxide Nanoparticles-based Contrast Agents for Magnetic Resonance Imaging

Mol Pharm, 2017;14(5):1352-1364.

Shen Z, Wu A, Chen X


Mapping Sentinel Lymph Node Metastasis by Dual-probe Optical Imaging 

Theranostics, 2017; 7(1):153-163.

Yang X, Wang Z, Zhang F, Zhu G, Song J, Teng G, Niu G, Chen X


Combination of nitric oxide and drug delivery systems: tools for overcoming drug resistance in chemotherapy

J Control Release, DOI: 10.1016/j.jconrel.2016.12.026

Kim J, Yung BC, Kim WJ, Chen X


Novel molecular “add-on” based on Evans Blue confers superior pharmacokinetics and transforms drugs to theranostic agents

J Nucl Med, 2017;58(4):590-597

Chen H, Jacobson O, Niu G, Weiss ID, Kiesewetter DO, Liu Y, Ma Y, Wu H, Chen X


Converting Red Blood Cells to Efficient Microreactors for Blood Detoxification

Adv Mater, 2016 Nov 28. doi: 10.1002/adma.201603673

Xu C, Yang X, Fu X, Niu G, Hu S, Ali I, Chen X


Clinical translation of a dual integrin αvβ3 and GRPR targeting PET radiotracer 68Ga-NOTA-BBNRGD

J Nucl Med. 2017;58(2):228-234. (Cover feature)

Zhang J, Niu G, Lang L, Li F, Fan X, Yan X, Yao S, Yan W, Huo L, Chen L, Li Z, Zhu Z, Chen X

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