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Wenyao Zhen

Research Fellow

Research Interest

Nanomedicines/Material science/et.al.

Education Background

Post-Doc., Department of Chemistry, University of Chicago, 2022-2024

Ph.D., Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 2021

Liang Zhao_edited_edited.jpg

B.Sc., Shool of Chemistry, Shandong Normal University

E-mail: wyzhen@nus.edu.sg

Publications


  1. Zhen, W.‡, Ziwan Xu.‡, Yibin Mao‡, Weichselbaum, R., Lin, W.* and et al., Nanoscale mixed-ligand metal-organic framework for X-ray stimulated cancer therapy. J. Am. Chem. Soc. 2024, doi: 10.1021/jacs.4c12140.

  2. Zhen, W.‡, Kang, D.‡, Weichselbaum, R., Lin, W.* and et al., Simultaneous protonation and metalation of a porphyrin covalent organic framework enhance photodynamic therapy. J. Am. Chem. Soc. 2024, 146, 16609-16618.

  3. Xu, Z.‡, Zhen, W.‡, Lin, W.* and et al. Nanoscale metal-organic framework with an X-ray triggerable prodrug for synergistic radiotherapy and chemotherapy, J. Am. Chem. Soc. 2023, 145, 18698-18704.

  4. Zhen, W.‡, Fan Y.‡, Weichselbaum, R., Lin, W.* and et al., Digitonin-loaded nanoscale metal-organic framework for mitochondria-targeted radiotherapy-radiodynamic therapy and disulfidptosis, Adv. Mater. 2024, 2405494.

  5. Zhen, W., Lin, W.* and et al. Nanoparticle‐mediated radiotherapy remodels the tumor microenvironment to enhance antitumor efficacy, Adv. Mater. 2022, 2206370.

  6. Zhen, W., Jiang, X.*, Li, J.* and et al. Precise subcellular organelle targeting for boosting endogenous-stimuli-mediated tumor therapy, Adv. Mater. 2021, 2101572.

  7. Zhen, W.‡, Germanas, T.‡, Weichselbaum, R. and Lin, W.*, Multifunctional nanomaterials mediate cholesterol depletion for cancer treatment, Angew. Chem. Int. Ed. 2024, doi: 10.1002/ange.202412844.

  8. Zhen, W., Jiang, X.* and et al. Glutathione‐induced in situ michael addition between nanoparticles for pyroptosis and immunotherapy, Angew. Chem. Int. Ed. 2023, 62, 2301866.

  9. Zhen, W.; Jiang, X.* and et al. Specific "unlocking" of a nanozyme-based butterfly effect to break the evolutionary fitness of chaotic tumors, Angew. Chem. Int. Ed. 2020, 59, 9491-9497.

  10. Zhen, W., Tian, H.*, Jiang, X.* and et al. BSA‐IrO2: catalase‐like nanoparticles with high photothermal conversion efficiency and a high X‐ray absorption coefficient for anti‐inflammation and antitumor theranostics, Angew. Chem. Int. Ed. 2018, 57, 10309-10313.

  11. Zhen, W., Jiang, X.* and et al. Multi-caged IrOx for facile preparation of "six-in-one" nanoagent for subcutaneous and lymphatic tumors inhibition against recurrence and metastasis, Adv. Funct. Mater. 2020, 30, 2002274.

  12. Zhen, W.‡, Luo, T.‡, Ralph R. Weichselbaum,* Lin, W.* and et al. Mechanoregulatory cholesterol oxidase-functionalized nanoscale metal-organic framework stimulates pyroptosis and reinvigorates T cells, Small 2023, 19, 2305440.

  13. Zhen, W., Chen, X.* Inflammasome-activating nanovaccine for cancer immunotherapy, Cancer Res. 2024, 84, 3709.

  14. Zhen, W., Jiang, X.* and et al. Reductive surfactant-assisted one-step fabrication of a BiOI/BiOIO3 heterojunction biophotocatalyst for enhanced photodynamic theranostics overcoming tumor hypoxia, Nanoscale Horiz. 2019, 4, 720-726.

  15. Zhen, W., Jiang, X.* and et al. Gram-scale fabrication of Bi@C nanoparticles through one-step hydrothermal method for dual-model imaging-guided NIR-II photothermal therapy, Nanoscale 2019, 11, 9906-9911.

  16. Zhen, W., Jiang, X.* and et al. Nanomaterials for regulation of tumor microenvironment and theranostics, Nanoscale Adv. 2020, 2, 1395-1409.

  17. Zhen, W.; Zhang, M.*, Jiang, X.* and et al. Multienzyme‐mimicking nanocomposite for tumor phototheranostics and normal cell protection, ChemNanoMat 2019, 1, 101-109.


Patents


  1. Jiang, X.; Zhen, W.; An, S.; Jia, X.; Wang, C. A BSA-Fe Spray Assisted New Mechanism of Wound Healing by Promoting the Growth of Fibroblasts. Chinese Patent, Application No. 201910668914.8, 2019.

  2. Jiang, X.; Zhen, W.; Jia, X.; Exploration and application of a bovine Serum Albumin-Tea Polyphenols-Metal nanocomplex. Chinese Patent, Application No. 202011594532.4, 2020.

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