Publications in 2025
1232
Spatiotemporal Nano-Regulator Unleashes Anti-Tumor Immunity by Overcoming Dendritic Cell Tolerance and T Cell Exhaustion in Tumor-Draining Lymph Nodes
Wang R, Li H, He S, Feng Y, Liu C, Hao K, Zhou D, Chen X, Tian H.
Adv Mater. 2025 Feb;37(5):e2412141. doi: 10.1002/adma.202412141. Epub 2024 Dec 11.
1231
Mineralized Supramolecular Microspheres with Immunoregulating Functions for Transarterial Chemoembolization Immunotherapy of Hepatocellular Carcinoma
Zhang M, Wang Y, Tang X, Zhang W, Mao Z, Yu Y, Yang X, Yu G, Chen X.
Small Methods. 2025 Oct 24:e00857. doi: 10.1002/smtd.202500857. Online ahead of print.
1230
Condensate nanovaccine adjuvants augment CD8(+) T-Cell-dependent antitumor immunity through mtDNA leakage-triggered cGAS-STING axis activation
Tang Y, Luo Z, Ma Z, Han L, Zhou Y, Liang T, Yang K, Zhao L, Chen X, Zhang P.
Signal Transduct Target Ther. 2025 Oct 21;10(1):349. doi: 10.1038/s41392-025-02447-w.
1229
Advanced Clinical Diagnosis of Malaria Using a Simple Red-Emissive Smart Fluorescent Probe
Ye Y, Zhang S, Chen G, Liu Z, Chen X, Luo R, Zhang Z, Zhao X, Lian J, Yang Z, Samanta S, Yang Z, Xu K.
Anal Chem. 2025 Oct 28;97(42):23555-23568. doi: 10.1021/acs.analchem.5c04953. Epub 2025 Oct 16.
1228
OsPIP2;1 Positively Regulates Rice Tolerance to Water Stress Under Coupling of Partial Root-Zone Drying and Nitrogen Forms
Kuang C, Han Z, Zhang X, Chen X, Gao Z, Zhu Y.
Int J Mol Sci. 2025 Oct 8;26(19):9782. doi: 10.3390/ijms26199782.
1227
Optimal Design of High-Critical-Current SMES Magnets: From Single to Multi-Solenoid Configurations
You H, Li H, Fu L, Shen B, Tang M, Chen X.
Materials (Basel). 2025 Oct 1;18(19):4567. doi: 10.3390/ma18194567.
1226
NIR-II Dual-Modal Photoacoustic and OCT/OCTA Contrast Mechanisms Imaging Microenvironment Responses for Precision-Guiding Tumor Photothermal Theranostics
Yang L, Li J, Ling S, Du F, Liao W, Li R, Li Y, Zhou Z, Jin Z, Chen X, Zhao Q.
Small Methods. 2025 Oct 13:e00955. doi: 10.1002/smtd.202500955. Online ahead of print.
1225
Dual Targeting of m(7)G tRNA Modification and Histone Acetylation using Carrier-Free Nano-Epidrugs to Evoke Osteosarcoma Chemosensitization
Qi L, Zhang W, Shi C, Feng C, Liu Z, Li Z, Fang F, Chen X.
Adv Mater. 2025 Oct 10:e05951. doi: 10.1002/adma.202505951. Online ahead of print.
1224
Programmable Bimetallic MOF Nanozyme Composite with Microenvironment-Adaptive Cascade Catalysis for Wearable Glucose Biosensing and Accelerated Diabetic Wound Healing
Yu K, Li X, Zhan S, Chai H, Cao X, Cao F, Guan J, Xu Q, Gao X, Qu L, Zhang X, Zhang G, Chen X.
Anal Chem. 2025 Oct 7;97(39):21668-21678. doi: 10.1021/acs.analchem.5c04419. Epub 2025 Sep 26.
1223
Unveiling Novel Viral Diversity, Biogeography, and Host Networks in Wildlife Through High-Throughput Sequencing Data Mining
Wang H, Meng Y, Chen X, Cui X, Zuo Q, Han N, Liang X, Shen X, Li C, Li D, Wang F, He L, Chen R, Lu X, You W, Wu A, Chen RA, Chen W, Ding C, Shen Y.
Adv Sci (Weinh). 2025 Sep 23:e11920. doi: 10.1002/advs.202511920. Online ahead of print.
1222
PPP1R3B Suppresses Atherosclerosis by Promoting the M2 Polarization of Macrophages Through Glycogen Metabolic Reprogramming
Shen L, Yu J, Chen W, Bi Y, Yang Z, Lu C, Jiang C, Yang Y, Chen M, Zou J, Lv L, Chen X, Ji J.
Adv Sci (Weinh). 2025 Sep 23:e06345. doi: 10.1002/advs.202506345. Online ahead of print.
1221
Dual role of Glossy15 in regulating flowering by modulating gibberellins and floral organ gene expression in maize
Yang J, Xu G, Zhang M, Xue W, Wu J, Li Y, Song G, Wang B, Liu Y, Chen X, Kong D, Wang H.
New Phytol. 2025 Nov;248(4):2143-2159. doi: 10.1111/nph.70492. Epub 2025 Sep 21.
1220
Advances in radiopharmaceuticals for cancer radiotheranostics: CCK2R targeting as a paradigm for translational innovation
Li J, Wen X, Reszegi RR, Kamalrhaj H, Parak WJ, Chen X, Zhang J.
Cancer Commun (Lond). 2025 Sep 20. doi: 10.1002/cac2.70063. Online ahead of print.
1219
Research Advances in AP2/ERF Transcription Factors in Rice Growth and Development
He Y, Li R, Li D, Fan X, Chen X, Zhuang C, Li J.
Plants (Basel). 2025 Aug 27;14(17):2673. doi: 10.3390/plants14172673.
1218
From Quantum Dots to Cancer Nanotheranostics
Chen X.
Nano Lett. 2025 Sep 24;25(38):13967-13969. doi: 10.1021/acs.nanolett.5c03619. Epub 2025 Sep 9.
1217
Bionic nanomedicines for microwave-triggered cuproptosis to enhance cancer immunotherapy
Suo M, Wang Z, Zhang S, Tang W, Liang D, Chen X, Ning S.
Nanoscale Horiz. 2025 Oct 20;10(11):3003-3012. doi: 10.1039/d5nh00425j.
1216
Nanomedicine Reimagined: Translational Strategies for Precision Tumor Theranostics
Wu Q, Yao X, Duan X, Chen X, Zhang J.
Adv Mater. 2025 Sep 6:e10293. doi: 10.1002/adma.202510293. Online ahead of print.
1215
Targeted ROS Scavenging for Disease Therapies Using Nanomaterials
Zhang Y, Zhang Y, Liang R, Zou J, Pei R, Chen X.
Adv Mater. 2025 Aug 22:e04435. doi: 10.1002/adma.202504435. Online ahead of print.
1214
Proteolysis-targeting chimera (PROTAC) nanomedicines toward cancer treatment: From synthesis to therapeutic delivery
Liu Y, Zhang X, Chen X, Zhang F.
Biomaterials. 2026 Feb;325:123621. doi: 10.1016/j.biomaterials.2025.123621. Epub 2025 Aug 8.
1213
Author Correction: Albumin-recruiting lipid nanoparticle potentiates the safety and efficacy of mRNA vaccines by avoiding liver accumulation
Feng Y, Tai W, Huang P, Qi S, Yu X, Li M, Li M, Zhang M, Cao F, Gao X, Yang K, Bai B, Lei J, Cheng M, Li Y, Cheng G, Chen X, Yu G.
Nat Mater. 2025 Nov;24(11):1862. doi: 10.1038/s41563-025-02343-2.
1212
Organoid-driven nanomedicine platform development
Wang J, Wang F, Jiang Y, Bai L, Chen X, Su J.
Biomaterials. 2026 Feb;325:123611. doi: 10.1016/j.biomaterials.2025.123611. Epub 2025 Aug 7.
1211
Albumin-recruiting lipid nanoparticle potentiates the safety and efficacy of mRNA vaccines by avoiding liver accumulation
Feng Y, Tai W, Huang P, Qi S, Yu X, Li M, Li M, Zhang M, Cao F, Gao X, Yang K, Bai B, Lei J, Cheng M, Li Y, Cheng G, Chen X, Yu G.
Nat Mater. 2025 Nov;24(11):1826-1839. doi: 10.1038/s41563-025-02284-w. Epub 2025 Aug 1.
1210
Trends in the development of cellular and gene therapy in China
Liu Y, Ge C, Chen X, Lu S, Wang T.
Nat Rev Drug Discov. 2025 Sep;24(9):656-657. doi: 10.1038/d41573-025-00126-7.
1209
Genetically engineered chondrocyte-mimetic nanoplatform attenuates osteoarthritis by blocking IL-1β and restoring sirtuin-3
Deng C, Yu L, Zhao X, Chen Y, Mei J, Wei J, Chen X, Lei G, Zeng C.
Sci Adv. 2025 Jul 25;11(30):eadv4238. doi: 10.1126/sciadv.adv4238. Epub 2025 Jul 25.
1208
The rise of China's pharmaceutical industry from 2015-2024: a decade of innovation
Liu S, Hu H, Ge C, Yuan S, Jiang J, Chen X.
Nat Rev Drug Discov. 2025 Oct;24(10):738-739. doi: 10.1038/d41573-025-00102-1.
1207
A Mesoporous Calcium Peroxide Nanocuboid with High Tumor Accumulation Across Biological Barriers for High Efficacy Tumor Therapy
Fan Q, Wang M, Lin J, Huang Y, Yang J, Zhu J, Ren B, Sun L, Li Z, Liu A, Xiong W, Wei Z, Huang L, Yan C, Wen G, Chen Z, Chen X, Shen Z.
Adv Sci (Weinh). 2025 Oct;12(39):e10778. doi: 10.1002/advs.202510778. Epub 2025 Jul 20.
1206
Metal-Phenolic Outer Membrane Vesicles for Cancer Radioimmunotherapy
Zhao C, Pan Y, Cao L, Tang Y, Chen X, Zhao X, Rao L.
J Am Chem Soc. 2025 Jul 30;147(30):26195-26207. doi: 10.1021/jacs.5c02774. Epub 2025 Jul 17.
1205
Establishment of an indirect ELISA for feline coronavirus antibody detection and serotype discrimination
Lu X, Hu Y, Chen X, Shen Y.
J Virol Methods. 2025 Dec;338:115224. doi: 10.1016/j.jviromet.2025.115224. Epub 2025 Jul 13.
1204
Microenvironment responsive nanoplatform for targeted removal of cholesterol and reshaping inflammatory microenvironment in atherosclerotic plaques
Shen L, Jiang C, Song J, Bi Y, Chen W, Lu C, Chen M, Lv L, Yu R, Zou J, Zhao Z, Chen X, Ji J.
J Control Release. 2025 Sep 10;385:114000. doi: 10.1016/j.jconrel.2025.114000. Epub 2025 Jul 6.
1203
Optogenetic engineering of lipid droplet spatial organization for tumor suppression
Bai Q, Shao X, Xia Q, Yang S, Gao Y, Sun K, Li J, Wang X, Tian Z, Chen X, Zhao J, Diao J, Chen Q.
Trends Biotechnol. 2025 Jul 1:S0167-7799(25)00217-3. doi: 10.1016/j.tibtech.2025.06.002. Online ahead of print.
1202
Smart ultra-long-lasting sequentially triggerable and artfully implantable nozzle system for on-demand drug delivery for chronotherapy
Zeng Q, Gong Y, Jiao W, Xu J, Chen X, Xu R, Liu Y, Liang X, Li G, Liu J, He L, Li W, Zhang X, Chen X, Chen W.
Sci Adv. 2025 Jun 27;11(26):eadv8734. doi: 10.1126/sciadv.adv8734. Epub 2025 Jun 25.
1201
Genistein Exudation Drives Spatial Root Allocation and Heterogeneous Microbial Communities to Enhance Phosphorus Acquisition in Soybean-Maize Intercropping
Zhang B, Jiang H, Zheng G, Zhang Z, Wang T, Chen Q, Chen X, Lu X, Liang C, Tian J.
Plant Cell Environ. 2025 Oct;48(10):7297-7312. doi: 10.1111/pce.70020. Epub 2025 Jun 22.
1200
High temperatures and microplastic enhanced inorganic phosphorus mineralization and phoD-harboring bacterial abundance in paddy soil
Afzal M, Tan X, Fang ML, Jin W, Liang Q, Wang X, Chen X, Zhang X, Tan Z.
Ecotoxicol Environ Saf. 2025 Sep 1;302:118495. doi: 10.1016/j.ecoenv.2025.118495. Epub 2025 Jun 17.
1199
Synthetic biology-driven induction of mature TLS formation enhances antitumor immunity in colorectal cancer
Mi Z, Chen J, Zhang Z, Liu J, Lei Y, Tan H, Li W, Chen X, Rong P.
Sci Transl Med. 2025 Jun 18;17(803):eado8395. doi: 10.1126/scitranslmed.ado8395. Epub 2025 Jun 18.
1198
The association between physical activity and lung function in adolescents: a cross-sectional NHANES study
Chen X, Ma J, Dong L, Chen Y, Chen K.
Front Med (Lausanne). 2025 Jun 3;12:1538221. doi: 10.3389/fmed.2025.1538221. eCollection 2025.
1197
A nanovaccine targeting cancer stem cells and bulk cancer cells for postoperative cancer immunotherapy
You Q, Wu G, Li H, Liu J, Cao F, Ding L, Liang F, Zhou B, Ma L, Zhu L, Wang C, Yang Y, Chen X.
Nat Nanotechnol. 2025 Sep;20(9):1298-1311. doi: 10.1038/s41565-025-01952-x. Epub 2025 Jun 16.
1196
Biomineral tablets for long-acting IL-2 immunotherapy
Liu J, Chen X.
Nat Cancer. 2025 Aug;6(8):1304-1306. doi: 10.1038/s43018-025-00951-0.
1195
Unconventional PROTACs for Targeted Protein Degradation in Cancer Therapy
Zhang X, Song Z, Zhang X, Zou J, Yu G, Chen X, Wang S.
Angew Chem Int Ed Engl. 2025 Jul 28;64(31):e202507702. doi: 10.1002/anie.202507702. Epub 2025 Jun 18.
1194
Rheumatoid arthritis and chronic obstructive pulmonary disease in US adults: a cross-sectional analysis
Mi P, Wang H, Fan G, Chen S, Chen X, Cao X, Feng H.
Front Med (Lausanne). 2025 May 23;12:1577180. doi: 10.3389/fmed.2025.1577180. eCollection 2025.
1193
Human induced pluripotent stem cell derived nanovesicles for cardiomyocyte protection and proliferation
Wei Y, Geng X, You Q, Zhang Y, Cao F, Narayanan G, Nguyen T, Chen X, Zhang J, Ye L.
Bioact Mater. 2025 May 2;50:585-602. doi: 10.1016/j.bioactmat.2025.04.017. eCollection 2025 Aug.
1192
Self-Assembled Fluorescent Peptide Nanoprobes for Disease Diagnosis
Wang R, Xi T, Li K, Wang C, Gao X, Yang H, Zou J, Chen X, Sun L.
Small Methods. 2025 Jun 1:e2500518. doi: 10.1002/smtd.202500518. Online ahead of print.
1191
A multi-dimensional comparative study of 505(b)(2) NDAs approved by FDA and Class 2 NDAs approved by NMPA from 2017 to 2023: Uncovering trends, characteristics, and regulation of modified new drugs
Fu L, Dong S, Xie R, Jia G, Zhao N, Xiang Q, Ji X, Zhao X, Chen X, Ma L, Cui Y.
Regul Toxicol Pharmacol. 2025 Nov;162:105864. doi: 10.1016/j.yrtph.2025.105864. Epub 2025 May 27.
1190
Patient reported outcomes in the FDA approved drugs for systemic rheumatic diseases (2013-2024)
Xie Y, Liu Y, Qin Y, Yin G, Chen X, Xie Q.
Health Qual Life Outcomes. 2025 May 28;23(1):52. doi: 10.1186/s12955-025-02386-8.
1189
Self-Promoting Targeted Delivery of Epigenetic Immunostimulants to Activate Breast Cancer Immunity via HDACs Downregulation and PD-L1 Upregulation
Chen X, Lu L, Liang Z, Yu B, Shao Z, Li J, Cen Y, Liu Y, Li S, Chen X.
Angew Chem Int Ed Engl. 2025 Jul 28;64(31):e202502120. doi: 10.1002/anie.202502120. Epub 2025 Jun 11.
1188
Nano-selenium mitigates arsenate toxicity in soybean roots by modulating phenylalanine and salicylic acid pathways
Zeeshan M, Khan AH, Salam A, Hu Y, Iqbal A, Hou R, Umar AW, Wu F, Chen X, Zhang Z.
BMC Plant Biol. 2025 May 26;25(1):699. doi: 10.1186/s12870-025-06726-0.
1187
Au(6)Cu(2) Clusters with High Electron Affinity and Oxygen-Mimetic Properties for Hypoxic Tumor Radiosensitization
Zhao X, Han J, Liu J, Wang ZY, Chen X, Zang SQ.
Angew Chem Int Ed Engl. 2025 Jul 21;64(30):e202504524. doi: 10.1002/anie.202504524. Epub 2025 May 24.
1186
An Environmentally Responsive Molecular Engineering Framework for Subcellular Drug Translocalization
Fang G, Liu D, Bai Q, Shao X, Liu Z, Yao Q, Yuan Y, Zeng K, Chen X, Chen X, Chen Q.
Adv Mater. 2025 Jul;37(29):e2503220. doi: 10.1002/adma.202503220. Epub 2025 May 13.
1185
Tumor microenvironment responsive nano-PROTAC for BRD4 degradation enhanced cancer photo-immunotherapy
Li Z, Ren G, Wang X, Li X, Ding L, Zhu J, Zhang Y, Zhang C, Zou J, Chen X.
Biomaterials. 2025 Nov;322:123387. doi: 10.1016/j.biomaterials.2025.123387. Epub 2025 May 7.
1184
Interspecific Mating Is Trivial and Asymmetrical Between Two Destructive Anoplophora Beetles
Xu T, Wang W, Chen X, Ma J, Chen R, Sun X, Yang Y, Li G, Deng Y, Hao D.
Insects. 2025 Mar 27;16(4):352. doi: 10.3390/insects16040352.
1183
Self-promoted tumor-targeting nanomedicine activates STING-driven antitumor immunity via photodynamic DNA damage and PARP inhibition
Yu B, Zhang W, Shao Z, Chen X, Cen Y, Liu Y, Chen Y, Li X, Liang Z, Li S, Chen X.
Chem Sci. 2025 May 1;16(22):9756-9765. doi: 10.1039/d5sc01953b. eCollection 2025 Jun 4.
1182
Bioinspired Claw-Engaged Adhesive Microparticles Armed with γGC Alleviate Ulcerative Colitis via Targeted Suppression of Macrophage Ferroptosis
Wang R, Zhu J, Zhou J, Li J, Wang M, Wu Y, Zhao D, Chen X, Chen X, Wang Y, Zou J.
Adv Sci (Weinh). 2025 Aug;12(30):e2503903. doi: 10.1002/advs.202503903. Epub 2025 Apr 29.
1181
Permanent Efferocytosis Prevention by Terminating MerTK Recycle on Tumor-Associated Macrophages for Cancer Immunotherapy
Huang P, Liu Y, Zhao C, Wang C, Wang L, Luo M, Wang W, Shan W, Liu X, Li B, Wang Z, Deng H, Chen X.
J Am Chem Soc. 2025 May 7;147(18):15901-15914. doi: 10.1021/jacs.5c05640. Epub 2025 Apr 28.
1180
Comparison of Al 18 F-NOTA-FAPI-74 and 18 F-FDG PET/CT in the Evaluation and Staging of Hepatobiliary Malignancies : A Single-center Prospective Study
Hou G, Cheng X, Jiang Y, Yang Y, Chen B, Huang Z, Li Z, Zhou A, Chen X, Zheng R, Zhao H, Zhang J, Wang X.
Clin Nucl Med. 2025 Jul 1;50(7):612-622. doi: 10.1097/RLU.0000000000005889. Epub 2025 Apr 24.
1179
Ruthenium Single-Atom Nanozyme Driven Sonosensitizer with Oxygen Vacancies Enhances Electron-Hole Separation Efficacy and Remodels Tumor Microenvironment for Sonodynamic-Amplified Ferroptosis
Zhu Y, Wang D, Du C, Wu T, Wei P, Zheng H, Li G, Zheng S, Su L, Yan L, Hu Y, Wang H, Lin L, Ding C, Chen X.
Adv Sci (Weinh). 2025 Jun;12(22):e2416997. doi: 10.1002/advs.202416997. Epub 2025 Apr 25.
1178
Amplifying X-ray-Induced Charge Transfer Facilitates Direct Sensitization of Photosensitizers in Radiotherapy
Zhang D, Chen Q, Zhang J, Xing X, Zhou Y, Ou X, Dai S, Chen Q, Liu X, Chen X, Zeng Y.
ACS Nano. 2025 May 6;19(17):16775-16793. doi: 10.1021/acsnano.5c01506. Epub 2025 Apr 25.
1177
Unlocking the Potential of Disulfidptosis: Nanotechnology-Driven Strategies for Advanced Cancer Therapy
Zhen W, Zhao T, Chen X, Zhang J.
Small. 2025 Jun;21(23):e2500880. doi: 10.1002/smll.202500880. Epub 2025 Apr 24.
1176
Nanotherapeutic Wee1 Inhibition Sensitizes Tumor Ferroptosis to Promote Cancer Immunotherapy and Abscopal Effect
Zhou P, Huang R, Cheng Y, Yang Y, Qian D, Ming X, Wang AZ, Chen X, Min Y.
ACS Nano. 2025 May 6;19(17):16307-16326. doi: 10.1021/acsnano.4c13218. Epub 2025 Apr 22.
1175
Visual recombinase aided amplification technology for detecting feline coronavirus
Lu X, Cao Y, Zhang P, Chen X, Irwin DM, Shen Y.
Vet J. 2025 Aug;312:106356. doi: 10.1016/j.tvjl.2025.106356. Epub 2025 Apr 12.
1174
PSMA-targeted radioligand therapy with [(177)Lu]Lu-LNC1011 for metastatic castration-resistant prostate cancer: a pilot study
Hou L, Wang Y, Fu H, Chen L, Yu C, Chen X, Zhang J.
Eur J Nucl Med Mol Imaging. 2025 Sep;52(11):4033-4043. doi: 10.1007/s00259-025-07245-8. Epub 2025 Apr 10.
1173
Molecular Imaging of B7-H3-Targeting Bispecific T Cell-Engaging Antibody MGD009 in Glioblastoma Models
Liu P, Ding H, Jia S, Pang Y, Li C, Zhao T, Skudder-Hill L, Wang J, Chen H, Zhao X, Chen X, Zhang J.
ACS Appl Mater Interfaces. 2025 Apr 16;17(15):22384-22393. doi: 10.1021/acsami.5c01451. Epub 2025 Apr 4.
1172
Safety, dosimetry, and efficacy of an optimized long-acting somatostatin analog for peptide receptor radionuclide therapy in metastatic neuroendocrine tumors: From preclinical testing to first-in-human study
Guo W, Wen X, Chen Y, Zhao T, Liu J, Tao Y, Fu H, Wang H, Xu W, Pang Y, Zhao L, Huang J, Xu P, Guo Z, Miao W, Zhang J, Chen X, Chen H.
Acta Pharm Sin B. 2025 Feb;15(2):707-721. doi: 10.1016/j.apsb.2024.05.022. Epub 2024 May 29.
1171
Role of genetic variants and DNA methylation of lipid metabolism-related genes in metabolic dysfunction-associated steatotic liver disease
Wang JJ, Chen XY, Zhang YR, Shen Y, Zhu ML, Zhang J, Zhang JJ.
Front Physiol. 2025 Mar 17;16:1562848. doi: 10.3389/fphys.2025.1562848. eCollection 2025.
1170
Optothermal-Stimulated Persistent Luminescence Imaging and Therapy (OSPLIT)
Pei P, Chen Y, Chen X, Zhang F, Liu X, Wang JW.
Adv Mater. 2025 May;37(21):e2500769. doi: 10.1002/adma.202500769. Epub 2025 Mar 31.
1169
Emerging patterns in nanoparticle-based therapeutic approaches for rheumatoid arthritis: A comprehensive bibliometric and visual analysis spanning two decades
Xie S, Liao P, Mi S, Song L, Chen X.
Open Life Sci. 2025 Mar 21;20(1):20251071. doi: 10.1515/biol-2025-1071. eCollection 2025.
1168
Bottom-Up Selective Growth of Ultralong Organic Phosphorescence Nanocrystals with Optimized Crystal Forms for In Vivo Optical Imaging
Chen J, Wei Z, Shan Y, Chen S, Wu Z, Liu S, Zhang J, Chen X, Liu B.
Adv Mater. 2025 May;37(19):e2418795. doi: 10.1002/adma.202418795. Epub 2025 Mar 24.
1167
Dansylated Amino Acid-Modified Long-Acting PSMA Derivatives (68)Ga/(177)Lu-LNC1011 as Prostate Cancer Theranostics
Yang H, Wang J, Wen X, Guo H, Jakobsson V, Zhao T, Zeng F, Shen H, Zhang H, Liu X, Qin Y, Li X, Xiong H, Zhou Z, Zhang J, Chen X.
J Nucl Med. 2025 May 1;66(5):739-747. doi: 10.2967/jnumed.124.268959.
1166
TLR4 mediates glucolipotoxicity-induced mitochondrial dysfunction in osteoblasts by enhancing NLRP3-MAVS expression and interaction
Shen X, Chen X, Zhong S, Zhang Y, Zhou X, Lan C, Lin J, Zheng L, Yan S.
Int Immunopharmacol. 2025 Apr 24;153:114438. doi: 10.1016/j.intimp.2025.114438. Epub 2025 Mar 17.
1165
Ultrasound-Activated Theranostic Materials and Their Bioapplications
Zhu K, Wang J, Wang Z, Chen Q, Song J, Chen X.
Angew Chem Int Ed Engl. 2025 May 26;64(22):e202422278. doi: 10.1002/anie.202422278. Epub 2025 Apr 3.
1164
177Lu-LNC1004 Radioligand Therapy in Patients with End-stage Metastatic Cancers: A Single-Center, Single-Arm, Phase II Study
Fu H, Huang J, Zhao L, Chen Y, Xu W, Cai J, Yu L, Pang Y, Guo W, Su B, Sun L, Wu H, Zhang J, Chen X, Chen H.
Clin Cancer Res. 2025 Apr 14;31(8):1415-1426. doi: 10.1158/1078-0432.CCR-24-3918.
1163
Comparison of [(68)Ga]Ga-Fibroblast Activation Protein Inhibitor-04 and [(18)F]FDG PET Imaging for Solitary Fibrous Tumor and Preliminary Application of FAP-Targeted Radiopharmaceutical Therapy
Wang R, Wang J, Xiang J, Sui H, Li L, Jia C, Peng X, Chen X, Zhu Z, Zhang J.
J Nucl Med. 2025 Apr 1;66(4):585-591. doi: 10.2967/jnumed.124.268258.
1162
Simultaneous Reversal of T Lymphocytes and Cancer Cells Metabolism Via a Biomimetic Heavy-Atom-Free Photosensitizers-Based Combination Therapies to Boost Cancer Photoimmunotherapy
Zhang Y, Wu X, Wang K, Tang Y, Lu X, Sun F, Tang H, Chen X, Ning S.
Adv Sci (Weinh). 2025 Apr;12(16):e2416143. doi: 10.1002/advs.202416143. Epub 2025 Mar 5.
1161
Self-Accelerated Nanoregulators for Positive Feedback Ferroptosis-Immunotherapy
Zhang X, Zhang X, Fan Q, Li J, Jia S, Chen X, Wang S.
Small. 2025 Apr;21(14):e2408156. doi: 10.1002/smll.202408156. Epub 2025 Mar 3.
1160
Genetically reprogrammed exosomes for cancer immunotherapy
Gu W, Tian Q, Xie T, Chen X.
Mol Ther. 2025 Mar 5;33(3):837-839. doi: 10.1016/j.ymthe.2025.02.009. Epub 2025 Feb 25.
1159
Development of [(225)Ac]Ac‑LNC1011 for targeted alpha-radionuclide therapy of prostate cancer
Wen X, Zhao T, Yang H, Shi M, Wee XJ, Fu J, Lin M, Zhang Z, Zou M, Green D, Wu X, Chen X, Zhang J.
Eur J Nucl Med Mol Imaging. 2025 Jul;52(8):2841-2855. doi: 10.1007/s00259-025-07155-9. Epub 2025 Feb 24.
1158
Pyridinium Rotor Strategy toward a Robust Photothermal Agent for STING Activation and Multimodal Image-Guided Immunotherapy for Triple-Negative Breast Cancer
Ning S, Shangguan P, Zhu X, Ou X, Wang K, Suo M, Shen H, Lu X, Wei X, Zhang T, Chen X, Tang BZ.
J Am Chem Soc. 2025 Mar 5;147(9):7433-7444. doi: 10.1021/jacs.4c15534. Epub 2025 Feb 20.
1157
Remodeling tumor microenvironment using prodrug nMOFs for synergistic cancer therapy
Dong J, Ding J, Luo S, Li R, Wang Y, Xiao B, Pei Y, Chen X, Sun W, Pei Z.
J Nanobiotechnology. 2025 Feb 19;23(1):123. doi: 10.1186/s12951-025-03202-7.
1156
Fibroblast Activation Protein Acts as a Biomarker for Monitoring ECM Remodeling During Aortic Aneurysm via (68)Ga-FAPI-04 PET Imaging
Hu C, Tan H, Zhang Y, Cao G, Wu C, Lin P, Qiu S, Mo F, Wang E, Li S, Yuan T, Li Z, Fu W, Cheng D, Lai H, Chen X, Wang L.
Adv Sci (Weinh). 2025 Apr;12(14):e2411152. doi: 10.1002/advs.202411152. Epub 2025 Feb 14.
1155
International approvals of cilta-cel: a lens on CAR T cell regulation
Ge C, Yin C, Chen X.
Nat Rev Clin Oncol. 2025 Apr;22(4):233-234. doi: 10.1038/s41571-025-00996-1.
1154
Contrasting cytotoxic and regulatory T cell responses underlying distinct clinical outcomes to anti-PD-1 plus lenvatinib therapy in cancer
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Cancer Cell. 2025 Feb 10;43(2):248-268.e9. doi: 10.1016/j.ccell.2025.01.001. Epub 2025 Jan 30.
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Breaking frontiers with multidisciplinary cancer research
Caldas C, Chen X, Ding L, Kather JN, Scaltriti M.
Nat Cancer. 2025 Jan;6(1):13-15. doi: 10.1038/s43018-024-00875-1.
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CaLu(2)Sc(2)Al(2)SiO(12):Ce(3+) Green Phosphors for High-Quality White LEDs
Chen X, Huang X.
Inorg Chem. 2025 Feb 10;64(5):2518-2528. doi: 10.1021/acs.inorgchem.4c05104. Epub 2025 Jan 29.
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Disruption of midgut homeostasis by microplastics in Spodoptera frugiperda: Insights into inflammatory and oxidative mechanisms
Fan Z, Khan MM, Wang K, Li Y, Jin F, Peng J, Chen X, Kong W, Lv X, Chen X, Qiu B, Wang X.
J Hazard Mater. 2025 Apr 5;487:137262. doi: 10.1016/j.jhazmat.2025.137262. Epub 2025 Jan 16.
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Gastrin-Releasing Peptide Receptor Targeting PET/CT With 68 Ga-NOTA-RM26 in the Assessment of Glioma and Combined Multiregional Biopsies
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Clin Nucl Med. 2025 Apr 1;50(4):316-323. doi: 10.1097/RLU.0000000000005651. Epub 2025 Jan 14.
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Preclinical and First-in-Human Study of a Compact Radionuclide Labeled Self-Assembly Nanomedicine for Chemo-Radio-Theranostics of Cancer
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ACS Nano. 2025 Jan 28;19(3):3953-3965. doi: 10.1021/acsnano.4c18489. Epub 2025 Jan 13.
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A Small-Molecule Drug for the Self-Checking of Mitophagy
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J Immunother Cancer. 2025 Jan 11;13(1):e010212. doi: 10.1136/jitc-2024-010212.
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Sequential Targeting Chondroitin Sulfate-Bilirubin Nanomedicine Attenuates Osteoarthritis via Reprogramming Lipid Metabolism in M1 Macrophages
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Adv Sci (Weinh). 2025 Mar;12(9):e2411911. doi: 10.1002/advs.202411911. Epub 2025 Jan 10.
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Adv Sci (Weinh). 2025 Feb;12(7):e2409551. doi: 10.1002/advs.202409551. Epub 2024 Dec 27.
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STING-Activating Polymers Boost Lymphatic Delivery of mRNA Vaccine to Potentiate Cancer Immunotherapy
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X-ray-activated nanoscintillators integrated with tumor-associated neutrophils polarization for improved radiotherapy in metastatic colorectal cancer
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