Publications in 2025
1166
PSMA-targeted radioligand therapy with [177Lu]Lu-LNC1011 for metastatic castration-resistant prostate cancer: a pilot study.
Hou L, Wang Y, Fu H, Chen L, Yu C, Chen X, Zhang J.
Eur J Nucl Med Mol Imaging. 2025 Apr 10. doi: 10.1007/s00259-025-07245-8.
1165
Ultrasound-Activated Theranostic Materials and Their Bioapplications.
Zhu K, Wang J, Wang Z, Chen Q, Song J, Chen X.
Angew Chem Int Ed Engl. 2025 Mar 17:e202422278. doi: 10.1002/anie.202422278.
1164
TLR4 mediates glucolipotoxicity-induced mitochondrial dysfunction in osteoblasts by enhancing NLRP3-MAVS expression and interaction.
Shen X, Chen X, Zhong S, Zhang Y, Zhou X, Lan C, Lin J, Zheng L, Yan S.
Int Immunopharmacol. 2025 Apr 24;153:114438. doi: 10.1016/j.intimp.2025.114438
1163
Dansylated Amino Acid-Modified Long-Acting PSMA Derivatives 68Ga/177Lu-LNC1011 as Prostate Cancer Theranostics.
Yang H, Wang J, Wen X, Guo H, Jakobsson V, Zhao T, Zeng F, Shen H, Zhang H, Liu X, Qin Y, Li X, Xiong H, Zhou Z, Zhang J, Chen X.
J Nucl Med. 2025 Mar 20:jnumed.124.268959. doi: 10.2967/jnumed.124.268959.
1162
Bottom-Up Selective Growth of Ultralong Organic Phosphorescence Nanocrystals with Optimized Crystal Forms for In Vivo Optical Imaging.
Chen J, Wei Z, Shan Y, Chen S, Wu Z, Liu S, Zhang J, Chen X, Liu B.
Adv Mater. 2025 Mar 24:e2418795. doi: 10.1002/adma.202418795.
1161
Optothermal-Stimulated Persistent Luminescence Imaging and Therapy (OSPLIT)
Pei P, Chen Y, Chen X, Zhang F, Liu X, Wang JW. Optothermal-Stimulated Persistent Luminescence Imaging and Therapy (OSPLIT).
Adv Mater. 2025 Mar 31:e2500769
1160
Safety, dosimetry, and efficacy of an optimized long-acting somatostatin analog for peptide receptor radionuclide therapy in metastatic neuroendocrine tumors: From preclinical testing to first-in-human study.
Guo W, Wen X, Chen Y, Zhao T, Liu J, Tao Y, Fu H, Wang H, Xu W, Pang Y, Zhao L, Huang J, Xu P, Guo Z, Miao W, Zhang J, Chen X, Chen H.
Acta Pharm Sin B. 2025 Feb;15(2):707-721
1159
Molecular Imaging of B7-H3-Targeting Bispecific T Cell-Engaging Antibody MGD009 in Glioblastoma Models
Liu P, Ding H, Jia S, Pang Y, Li C, Zhao T, Skudder-Hill L, Wang J, Chen H, Zhao X, Chen X, Zhang J.
ACS Appl Mater Interfaces. 2025 Apr 4. doi: 10.1021/acsami.5c01451
1158
177Lu-LNC1004 Radioligand Therapy in Patients with End-stage Metastatic Cancers: A Single-Center, Single-Arm, Phase II Study.
Fu H, Huang J, Zhao L, Chen Y, Xu W, Cai J, Yu L, Pang Y, Guo W, Su B, Sun L, Wu H, Zhang J, Chen X, Chen H.
Clin Cancer Res. 2025 Mar 14:OF1-OF12.
1157
Comparison of [68Ga]Ga-Fibroblast Activation Protein Inhibitor-04 and [18F]FDG PET Imaging for Solitary Fibrous Tumor and Preliminary Application of FAP-Targeted Radiopharmaceutical Therapy.
Wang R, Wang J, Xiang J, Sui H, Li L, Jia C, Peng X, Chen X, Zhu Z, Zhang J.
J Nucl Med. 2025 Mar 6:jnumed.124.268258.
1156
Simultaneous Reversal of T Lymphocytes and Cancer Cells Metabolism Via a Biomimetic Heavy-Atom-Free Photosensitizers-Based Combination Therapies to Boost Cancer Photoimmunotherapy.
Zhang Y, Wu X, Wang K, Tang Y, Lu X, Sun F, Tang H, Chen X, Ning S.
Adv Sci (Weinh). 2025 Mar 5:e2416143.
1155
Self-Accelerated Nanoregulators for Positive Feedback Ferroptosis-Immunotherapy.
Zhang X, Zhang X, Fan Q, Li J, Jia S, Chen X, Wang S.
Small. 2025 Mar 3:e2408156.
1154
Genetically reprogrammed exosomes for cancer immunotherapy.
Gu W, Tian Q, Xie T, Chen X.
Mol Ther. 2025 Mar 5;33(3):837-839.
1153
Development of [225Ac]Ac‑LNC1011 for targeted alpha-radionuclide therapy of prostate cancer.
Wen X, Zhao T, Yang H, Shi M, Wee XJ, Fu J, Lin M, Zhang Z, Zou M, Green D, Wu X, Chen X, Zhang J.
Eur J Nucl Med Mol Imaging. 2025 Feb 24. doi: 10.1007/s00259-025-07155-9.
1152
Pyridinium Rotor Strategy toward a Robust Photothermal Agent for STING Activation and Multimodal Image-Guided Immunotherapy for Triple-Negative Breast Cancer.
Ning S, Shangguan P, Zhu X, Ou X, Wang K, Suo M, Shen H, Lu X, Wei X, Zhang T, Chen X, Tang BZ.
J Am Chem Soc. 2025 Mar 5;147(9):7433-7444.
1151
Remodeling tumor microenvironment using prodrug nMOFs for synergistic cancer therapy.
Dong J, Ding J, Luo S, Li R, Wang Y, Xiao B, Pei Y, Chen X, Sun W, Pei Z.
J Nanobiotechnology. 2025 Feb 19;23(1):123.
1150
Fibroblast Activation Protein Acts as a Biomarker for Monitoring ECM Remodeling During Aortic Aneurysm via 68Ga-FAPI-04 PET Imaging.
Hu C, Tan H, Zhang Y, Cao G, Wu C, Lin P, Qiu S, Mo F, Wang E, Li S, Yuan T, Li Z, Fu W, Cheng D, Lai H, Chen X, Wang L.
Adv Sci (Weinh). 2025 Feb 14:e2411152.
1149
Breaking frontiers with multidisciplinary cancer research.
Caldas C, Chen X, Ding L, Kather JN, Scaltriti M.
Nat Cancer. 2025 Jan;6(1):13-15.
1148
Disruption of midgut homeostasis by microplastics in Spodoptera frugiperda: Insights into inflammatory and oxidative mechanisms.
Fan Z, Khan MM, Wang K, Li Y, Jin F, Peng J, Chen X, Kong W, Lv X, Chen X, Qiu B, Wang X.
J Hazard Mater. 2025 Apr 5;487:137262.
1147
Gastrin-Releasing Peptide Receptor Targeting PET/CT With 68 Ga-NOTA-RM26 in the Assessment of Glioma and Combined Multiregional Biopsies.
Wang R, Li Y, Li Z, Wang J, Li L, Xiang J, Jia C, Peng X, Wang Y, Ma W, Wang L, Jia W, Chen X, Li D, Zhu Z, Zhang J.
Clin Nucl Med. 2025 Apr 1;50(4):316-323.
1146
Preclinical and First-in-Human Study of a Compact Radionuclide Labeled Self-Assembly Nanomedicine for Chemo-Radio-Theranostics of Cancer.
Xiong H, Wang R, Zhang H, Zhang Q, Qin Y, Du C, Zhang X, Ye J, Shi C, Shen H, Zhu Z, Zhou Z, Chen X, Zhang J.
ACS Nano. 2025 Jan 28;19(3):3953-3965.
1145
A Small-Molecule Drug for the Self-Checking of Mitophagy.
Gao Y, Bai Q, Ren Y, Shao X, Zhang M, Wu L, Lewis SE, James TD, Chen X, Chen Q.
Angew Chem Int Ed Engl. 2025 Mar 3;64(10):e202421269.
1144
FAP-targeted radioligand therapy with 68Ga/177Lu-DOTA-2P(FAPI)2 enhance immunogenicity and synergize with PD-L1 inhibitors for improved antitumor efficacy.
Chen J, Zhou Y, Pang Y, Fu K, Luo Q, Sun L, Wu H, Lin Q, Su G, Chen X, Zhao L, Chen H.
J Immunother Cancer. 2025 Jan 11;13(1):e010212.
1143
Sequential Targeting Chondroitin Sulfate-Bilirubin Nanomedicine Attenuates Osteoarthritis via Reprogramming Lipid Metabolism in M1 Macrophages.
Deng C, Xiao Y, Zhao X, Li H, Chen Y, Ai K, Jiang T, Wei J, Chen X, Lei G, Zeng C.
Adv Sci (Weinh). 2025 Mar;12(9):e2411911.
1142
X-ray-activated nanoscintillators integrated with tumor-associated neutrophils polarization for improved radiotherapy in metastatic colorectal cancer.
Li H, Zeng J, You Q, Zhang M, Shi Y, Yang X, Gu W, Liu Y, Hu N, Wang Y, Chen X, Mu J.
Biomaterials. 2025 May;316:123031.