Zepeng He
Research Fellow
Research Interest
Design of targeted mRNA delivery systems, including lipid nanoparticle and ionizable lipid synthesis
Education Background
Ph.D., Materials Physics and Chemistry, Sun Yat-sen University, China, 2020-2025
B.Sc., Polymer Science and Engineering, Sun Yat-sen University, China, 2016-2020
E-mail: ZP.HE@nus.edu.sg
1. A Multidimensional Approach to Modulating Ionizable Lipids for High-Performing and Organ-Selective mRNA Delivery. Z. He, Z. Le, Y. Shi, L. Liu, Z. Liu*, Y. Chen* Angew. Chem. Int. Ed. 2023, 62, e202310401.
2. Chemical Design Strategy of Ionizable Lipids for In Vivo mRNA Delivery. Z. He, Z. Liu*, Y. Chen* ChemMedChem 2024, 19, e202400199.
3. Multicomponent reaction-based combinatorial chemistry for accelerating the discovery of therapeutic protein and nucleic acid delivery materials. Z. He#, Z. Le#, Z. Liu*, Y. Chen* NPG Asia Mater. 2025, 17, 14.
4. Impact of tail unsaturation in ionizable lipids on mRNA delivery efficiency and immunogenicity of lipid nanoparticles. X. Ge#, Z. He#, H. Yang, X. Pan, L. Yan, Y. Shi, Y. Chen, Z. Liu J*. Control. Release 2025, 384, 113906.
5. Cationic Lipid Pairs Enhance Liver-to-Lung Tropism of Lipid Nanoparticles for In Vivo mRNA Delivery. G. Zeng#, Z. He#, H. Yang, Z. Gao, X. Ge, L. Liu, Z. Liu*, Y. Chen* ACS Appl. Mater. Interfaces 2024, 16, 25698–25709.