Shuliang Gao
Research Fellow
Research Interest
RNA engineering, Protein design & Genetic modulation
Education Background
PhD, Bioengineering, East China University of Science and Technology, 2017
MSc, Bioengineering, East China University of Science and Technology, 2013
BSc, Bioengineering, Inner Mongolia University of Science and Technology, 2010
E-mail: sgao05@nus.edu.sg
1. Shuliang Gao, Mengting Chen, Douglas Wich, Hanan Bloomer, Zhiyuan Qu, Huiwen Guan, Qiaobing Xu*. ZUGC-RNA degradation generates immunosuppressor to evade immune responses in eukaryotes, bioRxiv, 2025
2. Shuliang Gao, Benson Weng, Douglas Wich, Liam Power, Mengting Chen, Huiwen Guan, Zhongfeng Ye, Chutian Xu, Qiaobing Xu*. Improving base editing precision by enlarging the recognition domain of CRISPR-Cas9, Nature Communications 2025, 16, 2081.
3. Shuliang Gao, Huiwen Guan, Bloomer Hanan, Douglas Wich, Donghui Song, Jennifer Khirallah, Zhongfeng Ye, Yu Zhao, Mengting Chen, Chutian Xu, Lihan Liu, Qiaobing Xu*. Harnessing non-Watson–Crick’s base pairing to enhance CRISPR effectors cleavage activities and enable gene editing in mammalian cells, Proc. Natl. Acad. Sci. U.S.A., 2024.1, 121(2): e2308415120.
4. Shuliang Gao, Qiaobing Xu*. New ionizable lipids reduce the lipid-to-mRNA ratio for base editing, National Science Review, 2024, 11(8): nwae224.
5. Shuliang Gao, Yangyang Tong, Li Zhu, Mei Ge, Yian Zhang, Daijie Chen, Yu Jiang, Sheng Yang*. Iterative integration of multiple-copy pathway genes in Yarrowia lipolytica for heterologous β-carotene production, Metabolic Engineering, 2017, 39(6): 192-201.
6. Shuliang Gao, Yangyang Tong, Zhiqiang Wen, Li Zhu, Mei Ge, Daijie Chen, Yu Jiang, Sheng Yang*. Multiplex gene editing of the Yarrowia lipolytica genome using the CRISPR-Cas9 system, Journal of Industrial Microbiology & Biotechnology, 2016, 43(8): 1085-1093.
7. Shuliang Gao, Yangyang Tong, Li Zhu, Mei Ge, Daijie Chen, Yu Jiang, Sheng Yang*. Production of β-carotene by expressing a heterologous multifunctional carotene synthase in Yarrowia lipolytica, Biotechnology Letters, 2017, 39(6): 921-927.
8. Shuliang Gao, Linna Han, Li Zhu, Mei Ge, Sheng Yang, Yu Jiang, Daijie Chen*. One-step integration of multiple genes into the oleaginous yeast Yarrowia lipolytica, Biotechnology Letters, 2014, 36: 2523-2528.