22 October 2023
The International Molecular Imaging Summit (IMIS 2023) was held in Xiamen
The International Molecular Imaging Summit (IMIS 2023)and Innovative Development and Clinical Translation Seminar on Radiopharmaceuticals were held in Xiamen from October 20th to 22nd. As a prominent and influential gathering in the field of molecular imaging, the event brought together over 500 industry elites, including academicians, medical scholars in the field of nuclear medicine, and entrepreneurs. They delivered keynote speeches, participated in specialized sub-forums, and deliberated on the future direction of molecular imaging.
On the morning of the 21st, the forum's opening ceremony was held, hosted by Professor Chen Xiaoyuan. In the keynote speech segment, Professor Chen Xiaoyuan presented a special report titled "Cancer Radiotheranostics." Using the development process of several market-approved radiopharmaceutical therapeutic drugs as examples, Professor Chen elaborated on the key aspects of drug development. He also shared the progress and remarkable clinical results of LanNaCheng's 177Lu-LNC1003, 177Lu-LNC1004, and 177Lu-LNC1011, earning the full recognition of industry experts. In the afternoon of the 21st, a special session on the development and clinical translation of radiopharmaceuticals featured presentations by several domestic and international experts and scholars. Professor Zhang Jingjing shared the research history of FAP-targeted therapeutic drugs, from the early 177Lu-FAPI-2286 to the EB-modified 177Lu-LNC1004, using clinical treatment outcomes as examples, vividly showcasing the surprising clinical efficacy of FAP-targeted radiopharmaceutical therapy.
29 September 2023
Congulations! Zunyong’s recent work was accepted by Nature Cancer!
Recently, Zunyong’s work based on An in vitro-transcribed circular RNA targets the mitochondrial inner membrane cardiolipin to ablate EIF4G2+/PTBP1+ pan-adenocarcinoma has been accepted by Nature cancer. This is our first paper in this journal.
In vitro-transcribed (IVT) mRNA has arisen as a rapid method for the production of nucleic acid drugs. Here, we have constructed an oncolytic IVT mRNA that utilizes human rhinovirus type 2 (HRV2) internal ribosomal entry sites (IRESs) to selectively trigger translation in cancer cells with high expression of EIF4G2 and PTBP1. The oncolytic effect was provided by a long hGSDMDc .825 T>A/c.884 A>G-F1LCT mutant mRNA sequence with mitochondrial inner membrane cardiolipin targeting toxicity that triggers mitophagy. Utilizing the permuted intron-exon (PIE) splicing circularization strategy and lipid nanoparticle (LNP) encapsulation reduced immunogenicity of the mRNA and enabled delivery to eukaryotic cells in vivo. Engineered HRV2 IRESs-GSDMDp.D275E/E295G-F1LCT circRNA-LNPs (GSDMDENG circRNA) successfully inhibited EIF4G2+/PTBP1+ pan-adenocarcinoma xenografts growth. Importantly, in a spontaneous tumor model with abnormal EIF4G2 and PTBP1 caused by KRAS G12D mutation, GSDMDENG circRNA significantly prevented the occurrence of pancreatic, lung and colon adenocarcinoma, improved the survival rate and induced persistent KRAS G12D tumor antigen-specific cytotoxic T lymphocyte responses.
Please see more details in: https://doi.org/10.1038/s43018-023-00650-8
7 August 2023
Zhejiang University's School of Pharmacy collaborated in a joint workshop alongside students from the Yong Loo Lin School of Medicine.
On August 7th, undergraduates and doctoral students from Zhejiang University's School of Pharmacy participated in a joint workshop with students from the Yong Loo Lin School of Medicine. The workshop was focused on fostering student exchange and collaboration in the field of biomedical sciences between the two institutions. Several graduate students delivered oral presentations and engaged in discussions related to their research work within the realm of biomedicine. Meanwhile, undergraduates from Zhejiang University's School of Pharmacy conducted a comparative analysis of "Curriculum Development and Course Offerings in Pharmacy Programs: A Case Study of the National University of Singapore and Zhejiang University."
This collaborative event provided a platform for students and scholars from both universities to engage in meaningful discussions and knowledge sharing within the context of biomedical research and education. The workshop not only facilitated valuable cross-cultural and cross-institutional interactions but also contributed to the advancement of expertise and perspectives in the field of pharmaceutical sciences. Such initiatives enhance the overall academic experience and promote international cooperation among educational institutions.
6 August 2023
Welcome! Prof. Gu Zhen from Zhejiang University visit Yong Loo Lin School of Medicine.
On August 6th, Professor Gu Zhen, the Dean of Zhejiang University's School of Pharmacy, along with his team members, paid a visit to the Yong Loo Lin School of Medicine at the National University of Singapore. During this visit, Professor Gu Zhen delivered a captivating presentation titled "Bioresponsive Bioinspired Drug Delivery," which captured the keen interest of the attending audience. The response was highly enthusiastic, carrying a significant positive impact on advancing research in related fields and fostering academic exchanges among universities.
Moreover, Professor Gu provided insights into the developmental trajectory of Zhejiang University's School of Pharmacy and reflected upon the collaborative accomplishments achieved with Singaporean universities in recent years. He conveyed his anticipation for forging even stronger international collaborative relationships. The visiting delegation immersed themselves in substantial discussions with their counterparts from the host institutions, centering on crucial themes including international talent cultivation, research collaboration, and knowledge dissemination. A unanimous consensus emerged to actively propel the internationalization of talent development and to establish a collaborative consortium focused on pharmaceutical sciences. The overarching objective is to collectively drive innovation and transformative progress within the realm of biomedicine.
This visit and ensuing exchange distinctly underscore the cooperative engagement and cross-institutional discourse at an international level. The endeavor prominently accentuates the vigorous pursuit of breakthroughs in pharmaceutical research. The palpable enthusiasm evoked by Professor Gu's presentation underscores the profound import of such scholarly exchanges, not only propelling advancements but also nurturing synergistic partnerships among universities.
14 July 2023
Three-course meal from Prof. Kam. Leong, Prof. Jackie Ying and Prof. Guangjun Nie
Recently, Prof. Chen hosted a l mini-symposium for the Nanomedicine TRP program in LT37. The Specialists Accreditation Board (SAB) members, Prof. Kam. Leong, Prof. Jackie Ying, and Prof. Guangjun Nie, were invited to give presentations. As experts in their respective fields, the presentations delivered by the SAB members provided valuable insights and expertise to the audience. Their contributions enhanced the understanding of the program's progress and the cutting-edge research being conducted. The audience was actively questioning after the meeting. This symposium fostered a collaborative environment for knowledge exchange and idea sharing.
13 July 2023
Congratulations on the successful Nanomedicine TRP Programme interim report meeting!
During the meeting held in MD6, the Specialists Accreditation Board (SAB) members were invited to participate. Prof. Chen provided an overview of the aims and research progress of the TRP program, highlighting completed work, milestones achieved, and the project timeline. The PIs within the TRP program shared recent research progress and discussed their group's plans for the next phase. Additionally, presentations were delivered by PhD students and research fellows, who also addressed questions posed by the SAB members.
The SAB members' valuable comments and suggestions for the program will undoubtedly contribute to further improvements and success in the future. The encouragement given to the PIs and their teams for their exceptional findings and achievements will be a motivating factor as the program continues. Once again, congratulations on a successful interim report meeting, and may the Nanomedicine TRP Programme continue to thrive and make significant contributions to the field!
3 July 2023
Congratulations! Prof. Chen was invited to join the Advanced Materials Hall of Fame.
Recently, Prof. Chen has been invited to join the Advanced Materials Hall of Fame. This honor recognizes researchers who have made significant advancements and demonstrated leadership in the field of materials science. Over the past thirty years, Advanced Materials journal has witnessed remarkable progress in various scientific disciplines and has published numerous groundbreaking achievements in the field. Congratulations to Professor Chen!
Please follow the link to the Hall of Fame article to stay updated on the latest top contributions in the Hall of Fame series.：
6 July 2023
Novel PET radiotracer successfully detects multiple cancers, offers potential for new targeted radionuclide therapy
A new radiotracer, 68Ga-FAP-2286, has been found to be more effective than the most commonly used nuclear medicine cancer imaging radiotracer, 18F-FDG. In a study published in the March issue of The Journal of Nuclear Medicine, 68Ga-FAP-2286 detected 100 percent of primary tumors across multiple cancer types as compared to 18F-FDG, which identified only 80 percent. 68Ga-FAP-2286 was also more effective in detecting lymph node metastases and distant metastases.
Chen noted that FAP-2286 not only exhibits promising characteristics for diagnosis, but also for cancer treatment. “Due to its molecular makeup, FAP-2286 can be paired with 177Lu to create a new radiopharmaceutical therapy,” he said. “177Lu-FAP 2286 has the potential to offer potent and selective FAP binding, which could lead substantial therapeutic efficacy for cancer patients in the future.”
This study was made available online in September 2022. See more details at: https://www.eurekalert.org/news-releases/982979
1 July 2023
Prof. Chen gave progress report at the 2023 Annual Meeting of the SNMMI in North America on behalf of LNC
Recently, at the 2023 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging (SNMMI) in North America, the nuclear medicine products and research achievements of LNC, a subsidiary of Dongcheng Pharmaceutical Holdings, attracted widespread attention and acclaim.
At this SNMMI annual meeting, LNC achieved remarkable results, showcasing its cutting-edge technology and research achievements in nuclear medicine. Professor Chen and Professor Zhang Jingjing delivered progress reports.
Professor Chen gave a keynote presentation during the "FAP Satellite Symposium: FAP ligands for Imaging and Therapy," where he introduced the 177Lu-LNC1004 product (targeting fibroblast activation protein FAP for radiotherapy of solid tumors) and its clinical research progress, along with the latest industry developments. As the Chief Medical Officer (CMO) of LNC, Professor Zhang Jingjing orally presented the first human study of a novel SSTR antagonist, 68Ga-DATA5m-LM4, in patients with metastatic neuroendocrine tumors. This exciting research received the SNMMI 2023 Travel Award and the SNMMI 2023 International Best Abstract for Singapore.
Professor Chen Xiaoyuan also delivered an oral presentation at the conference on the research progress of the 177Lu-LNC1003 product (targeting prostate-specific membrane antigen PSMA) and showcased the preclinical and clinical research results of 177Lu/225Ac-LNC1003 for prostate cancer radioligand therapy. The performance of this product in prostate cancer treatment surpassed the FDA-approved 177Lu-PSMA-617 and the previously researched 177Lu-EB-PSMA by the team.
These showcased achievements at the SNMMI annual meeting once again demonstrate BlueNachiBio's innovative capabilities and technical strength in the field of nuclear medicine and oncology diagnosis and treatment. LNC's groundbreaking research brings new hope to cancer patients and demonstrates the influence and competitiveness of China's nuclear medicine field internationally.
28 June 2023
Theranostics got the latest Journal Impact Factor (IF) of 12.4!
Theranostics has just received its latest Impact Factor for the year 2022, which is 12.4. It ranks 8th among 136 comprehensive journals worldwide in the field of medical research and experimental studies, placing it in the top tier of JCR Q1. Congratulations!
Theranostics journal is dedicated to integrated research in clinical and basic medicine. It primarily publishes articles and review papers on molecular diagnostics in vivo and in vitro, tumor treatment, targeted therapy, biological therapy, nanomedicine, translational medicine, as well as basic biomedical research. Welcome to submit your manuscript to Theranostics.
7 July 2022
Congratulations to Dr. Zou for receiving the funding support from the National Medical Research Council.
Dr. Jianhua Zou has been awarded a 2-year duration Open Fund Young Individual Research Grant (OFYIRG) by the National Medical Research Council (NMRC), Ministry of Health (MOH). Congratulations!
26 June 2023
Congratulations to Mengyao for receiving the funding support from the National Medical Research Council.
Dr. Mengyao Zhao has been awarded a 3-year duration Open Fund Young Individual Research Grant (OFYIRG) by the National Medical Research Council (NMRC), Ministry of Health (MOH). Congratulations!
29 May 2023
Prof. Chen: There exists no shortcut to achieving excellence in science, this journey can only be covered by taking one step at a time.
Prof. Chen was recently invited to an interview with Wiley about his inspiration for science research. He believes that the research career is a long journey. One needs to have a consistent dedication to always pursue the next peak throughout his time as a researcher. A firm determination is also a key to unlocking the truth. More importantly, a distinct research direction that the researcher is passionate about is of equal significance. In Prof. Chen's eyes, scientific research can always be interesting and charming. If you don't appreciate or enjoy the beauty, then it's no more than a miserable boring work. He endeavors to culture the students to take initiative in their work, has the potential to carry out scientific research independently, think critically, and always keep that curiosity to discover and innovate while, of course, having a good theoretical and experimental foundation. See more information: https://mp.weixin.qq.com/s/hEVG785b0CxVHApJ8IMX-g
2 April 2023
What a great getaway and gathering in Johor Malaysia!
This weekend, the extended TNT Chen group held the OFFICIAL First overseas lab bonding in Johor, Malaysia. Prof. Chen planned and led the lab outing with diverse activities and entertainment to create a space of relief and motivation for the lab and, more importantly, to bring everyone’s heart together in this family. Members had much fun and enjoyed themselves in this trip. Thanks to a wonderful trip among the rich research life. Wish our group more glory and achievement in the future!
4 April 2023
Dr Sadra Bakhshandeh is invited to give a seminar on how to write for Nature Reviews Journals.
Dr Sadra Bakhshandeh was trained as a mechanical engineer and moved to biomedical engineering and medical biotechnology at the Max Planck Institute for Colloids and Interfaces in Germany. He has now been working as an editor at Nature Reviews Bioengineering for more than a year. Dr Sadra Bakhshandeh introduced Nature Reviews Bioengineering, how it differs from Nature Research journals, and the type of content we cover in the first part of the seminar. After that, he talked about the skills of writing for Nature Reviews journals and gave his suggestions for the authors.
27 March 2023
Professor Li Jun from Department of Biomedical Engineering is invited to give a seminar under the topic of self-assembled nanocarrier systems.
Dr. Li Jun is a Professor in Biomedical Engineering at National University of Singapore (NUS). Before joining NUS, he worked as a Senior Scientist at the A*STAR Institute of Materials Research and Engineering, and as a Special Postdoctoral Researcher at the RIKEN Institute in Japan. He received his PhD (1995) and MSc (1992) in macromolecular science from Osaka University, Japan. Prof. Li’s expertise lies across the synthetic and bio-based polymers, and their supramolecular self-assemblies forming nanostructures for various applications such as drug and gene delivery, tissue engineering, personal care, and environmental sustainability. So far, he has published more than 200 international journal articles, which have received more than 15,000 citations with an h-index of 69. He filed 12 patents, authored a few book chapters, and edited one research book. He served chairs/co-chairs for 6 international symposia/conferences on the topics of bio-based polymers, hydrogels, and biomaterials, and supramolecular chemistry.
Prof. Li Jun’s research group in Department of Biomedical Engineering of NUS has been working on developing novel supramolecular self-assembled biomaterials starting from bio-based polymers and synthetic polymers as building blocks. It has been a challenge to incorporate multiple functional features into a single drug and gene carrier system to overcome numerous hurdles during the delivery of drugs and genes. Prof. Li Jun demonstrated several examples for building multifunctional carrier systems with controllable molecular architectures based on supramolecular self-assemblies including micelles, hydrogels, and nanoparticles.
Professor Phei Er Saw from Sun Yat-sen University was invited to give a Research Seminar in the Nanomedicine Translation Research Program
Prof. Phei Er Saw is an excellent scientist in the field of bio-nanomedicine, with an emphasis on developing novel lipid nanoparticles as well as understanding the uptake mechanisms of lipid-based nanoparticles for cancer therapy. Her prior research combined the development of novel lipid-based nanoparticles, micelles, bicelles, and liposome synthesis as well as drug and siRNA encapsulation and targeted delivery in vitro and in vivo. In her new position in Sun Yat-sen Memorial Hospital, she now focusing on using various bioresponsive nano-delivery system to target and modulate TME for immunotherapy. She is also developing fully natural bio-active nanomedicine for medical application.
Prof. Phei Er Saw gave her speech entitled “Tumor microenvironment (TME)-modulating nanoparticles for cancer therapy”. She summarized the various pathways that one could make use of the unique TME (i.e. high ROS, lower pH, etc.) to develop TME-modulating nanoparticles for the delivery of chemotherapeutics and biologics. Meanwhile, she introduced the concept of “back to nature”, to fully utilize natural materials as nanoparticles that could lead to synergistic anti-cancer properties.
22 December 2022
Congratulations! Zhu Yang's recent work has been accepted by ACS Nano
Zhu Yang’s paper entitled with “Enhancing Catalytic Activity of a Nickel Single Atom Enzyme by Polynary Heteroatom Doping for Ferroptosis-Based Tumor Therapy” was accepted by ACS Nano.
As a rising generation of nanozymes, single-atom enzymes show significant promise for cancer therapy, due to their maximum atom utilization efficiency and well-defined electronic structures. However, it remains a tremendous challenge to precisely produce a heteroatom-doped single-atom enzyme with an expected coordination environment. Herein, we develop an anion exchange strategy for precisely controlled production of an edge-rich sulfur (S)- and nitrogen (N)-decorated nickel single-atom enzyme (S-N/Ni PSAE). In particular, sulfurized S-N/Ni PSAE exhibits stronger peroxidase-like and glutathione oxidase-like activities than the nitrogen-monodoped nickel single-atom enzyme, which is attributed to the vacancies and defective sites of sulfurized nitrogen atoms. Moreover, both in vitro and in vivo results demonstrate that, compared with nitrogen-monodoped N/Ni PSAE, sulfurized S-N/Ni PSAE more effectively triggers ferroptosis of tumor cells via inactivating glutathione peroxidase 4 and inducing lipid peroxidation. This study highlights the enhanced catalytic efficacy of a polynary heteroatom-doped single-atom enzyme for ferroptosis-based cancer therapy.
14 December 2022
Professor Chunming Wang was invited to give a research Seminar in the Nanomedicine Translation Research Program
Prof. Chunming Wang from Macau University was invited to give a research seminar entitled with “Modulating macrophages with microbe- and tumourinspired approaches for tissue repair”. Chunming is an old friend of NUS, he got his PhD degree in NTU and worked in A*STAR for many years.
He shared his recent research in this seminar, focusing on the development of glycan biomaterials and cell therapies for modulating the immune niche for promoting tissue regeneration. He has won multiple research grants at national and regional levels, been elected as a Fellow of both the Royal Society of Biology and Royal Society of Chemistry, UK, and serves on the editorial board of Bioactive Materials. Prof. Wang’s research was published in a series of peer-reviewed journal such as Nature Communications, Science Advances, EMBO Molecular Medicine, Gut, and Advanced Materials, etc.
4 December 2022
Highlighted on Medical News! Prof Chen and the Team developed new series of LNP carriers.
Lipid nanoparticle (LNP)-based messager mRNA vaccines have emerged as a promising strategy for the prevention and treatment of cancer. Efforts have been made worldwide to improve the current design of the particles to address the side effects.
In our recent work published on Advanced Materials (Huang, P., et al.), Prof Chen and the group in NUS developed potent yet low inflammatory mRNA cancer vaccine vectors. The team synthesised a series of alternating copolymers instead of LNP, which can work as vehicles and help mRNA cargos deliver into cells. After entry into cells, mRNA is translated into protein antigens and kills the disease. In the process, the stability of polymeric nanoparticles (PNP) is maintained, which can ensure the accurate transmission of all genetic information to the targeted action sites of the antigen to kill the disease. This ensures the efficacy and safety of the vaccine.
This work was highlighted by www.news-medical.net. Full news article available at: https://www.news-medical.net/news/20221204/Researchers-develop-potent-yet-low-inflammatory-mRNA-cancer-vaccine-vectors.aspx .
29 November 2022
Congratulations! Zheng Li's recent review has been accepted by AM.
Zheng’s review paper entitled with “In Response to Precision Medicine: Current Subcellular Targeting Strategies for Cancer Therapy” was accepted by Adv. Mater. Congratulations to Zheng!
Emerging as a potent anti-cancer treatment, subcellular targeted cancer therapy has drawn increasing attention, bringing great opportunities for clinical application. In this review, we summarize two targeting strategies for four main subcellular organelles (mitochondria, lysosome, endoplasmic reticulum, and nucleus), including molecule and nanomaterial (inorganic nanoparticles, micelles, organic polymers, and others)-based targeted delivery or therapeutic strategies. Phototherapy, chemotherapy, radiotherapy, immunotherapy, and “all-in-one” combination therapy are among the strategies covered in detail. Such materials have been constructed based on the specific properties and relevant mechanisms of organelles, enabling the elimination of tumors by inducing dysfunction in the corresponding organelles or destroying specific structures. The challenges faced by organelle-targeting cancer therapies are also summarized. Looking forward, we envision a paradigm for organelletargeting therapy with enhanced therapeutic efficacy compared to current clinical approaches.
15 November 2022
Congratulations! Prof. Chen was recently recognized among the outstanding Highly Cited Researchers (2022) worldwide.
Published last month, Professor Chen was recognized as one of the most influential scientific minds in the field of both Chemistry and Materials Science, based on the Highly Cited Researchers 2022 List published by data analytics firm Clarivate.
The Highly Cited Researchers 2022 list uses both quantitative and qualitative analysis to identify individuals from across the globe who have demonstrated significant and broad influence in their chosen field or fields of research. This year, 7,225 researcher awards (issued to 6,938 individuals) from 69 countries and regions were announced – 3,981 in specific fields and 3,244 for cross-field impact. The list is drawn from highly cited papers that rank in the top 1 percent by citations for field and publication year in the Web of Science citation index over the past decade. The list also identifies the research institutions and regions where they are based.
Prof. Chen is among a total of 34 researchers awarded in NUS. He has made a significant contribution to translating research breakthroughs to practice. His tremendous effort in transforming science and nurturing next-generation scientists is highly acknowledged in the field.
Congrats Professor Chen for this honor!
23 November 2022
Professor Wanjin Hong from A*STAR was invited to give an invited Research Seminar in the Nanomedicine Translation Research Program
Prof. Wanjin Hong is the Executive Director of IMCB in A*STAR. He was the recipient of Singapore’s National Science Award in 1999 and a Fellow of Singapore National Academy of Science since 2022. He is on the Board of Reviewing Editors of Science Signaling and the Editorial Boards of Cell & Bioscience and TRAFFIC.
Prof. Hong was invited to give a seminar entitled with “The Hippo Pathway: Players, Regulators, and Cancer Targeting”. The Hippo signaling pathway is involved in normal cell growth and homeostasis, and when dysregulated, implicated in various cancers. Transcriptional co-regulators YAP/TAZ act downstream of Hippo signaling. When Hippo pathway is inactive, YAP/TAZ are hypo-phosphorylated & translocated into the nucleus to bind to TEAD family of transcription factors, activating gene transcription program responsible for proliferation and repair of cells, tissues & organs. These compounds accelerated wound closure in a mouse wound-healing model, highlighting the potential of targeting TEAD in the context of regenerative medicine in addition to cancer therapy.
11 November 2022
Congrats to Prof. Chen for the Best Scientist Award!
Nowadays, Prof. Chen was rewarded as the Best Scientist Award by Research.com. with high ranking of in the world (700) and in Singapore (4).
The best scientist award to the top 10000 scientist was selected from 166,880 scientists in all major fields of science. Prof. Chen’s recent research focus on Nanotechnology, In vivo, Nanoparticle, Molecular imaging and Integrin. His paper has been cited over 113,000 times in total. Congrats to Prof. Chen!
See mor details in https://research.com/u/xiaoyuan-chen .
3 November 2022
Congratulations to Pei Huang
Pei's research article entitled with "Integrated Polymeric mRNA Vaccine without Inflammation Side-Effects for Cellular Immunity Mediated Cancer Therapy" was accepted by Adv. Mater. Congratulations to Pei!
Among the few available mRNA delivery vehicles, lipid nanoparticle (LNP) is the most clinically advanced one but requires cumbersome four components and suffers from inflammation-related side effects which should be minimized for safety. Yet, a certain level of proinflammatory responses and innate immune activation is required to evoke T-cell immunity for mRNA cancer vaccination. To address these issues and develop potent yet low-inflammatory mRNA cancer vaccine vectors, we synthesized a series of alternating copolymers “PHTA” featured with ortho-hydroxy tertiary amine (HTA) repeating units for mRNA delivery, which can play triple roles of condensing mRNA, enhancing the polymeric nanoparticle (PNP) stability, and prolonging circulation time. Unlike the LNPs exhibiting high levels of inflammation, the PHTA-based PNPs showed negligible inflammatory side effects in vivo. Importantly, the top candidate PHTA-C18 enabled successful mRNA cancer vaccine delivery in vivo and led to a robust CD8+ T cell-mediated antitumor cellular immunity. Such PHTA-based integrated PNP provides a potential approach for establishing mRNA cancer vaccines with good inflammatory safety profiles.
18 October 2022
Prof. Ling Peng from Aix-Marseille University & CNRS UMR was invited to give an invited lecture in the Nanomedicine Translation Research Program.
Prof. Ling Peng gave a talk titled with Modular & Adaptive supramolecular dendrimers for biomedical applications in Chen Lab on 18th, Oct. 2022.
Prof. Ling Peng is a leading expert in developing functional dendrimer nanosystems for biomedical applications such as delivery of anticancer drugs, nucleic acid therapeutics and imaging agents. Her team has been labelled by La Ligue contre Le Cancer for developing nanomedicine in cancer therapy.
She presented her recent studies on modular and adaptive dendrimer nanosystems, constructed via self-assembling of amphiphilic dendrimers, for the delivery of imaging agents, anticancer drugs and nucleic acid therapeutics for cancer detection and treatment. The self-assembling approach to create supramolecular dendrimer is completely novel in concept yet easy to implement in practice, offering a fresh perspective for exploiting the advantageous features of supramolecular dendrimers in biomedical applications.
29 September 2022
Congratulations to Mengyao
Mengyao's research paper titled with "A LRET Nanoplatform Consisting of Lanthanide and Amorphous Manganese Oxide for NIR-II Luminescence Lifetime Imaging of Tumor Redox Status" was accepted by Angew. Chem. Congratulations to Mengyao!
Designing luminescence lifetime sensors in the second near-infrared (NIR-II) window is a great challenge due to the difficult structural construction. Here, we report a tumor redox responsive and easily synthesized material, amorphous manganese oxide (MnOx) with indirect band gap of 1.02 eV, as an energy acceptor to build a luminescence resonance energy transfer (LRET) toolbox for universally regulating NIR-I to NIR-II luminescence lifetimes of lanthanide nanoparticles, in which energy transfer is based on matched energy gap instead of conventional overlapped spectra. We further utilize ytterbium (Yb3+)-doped YbNP@MnOx as an NIR-II luminescence lifetime sensor to realize in vitro quantitative redox visualization with relative errors under 5 % in samples covered with mouse skin. Furthermore, HepG2 cells and tumors with high redox state have been accurately distinguished by NIR-II luminescence lifetime imaging. The quantified intracellular and intratumor glutathione (GSH) levels are highly consistent with the commercial kit results, illustrating the reliable redox visualization ability in biological tissue.
20 September 2022
Prof. Wolfgang Parak from Universität Hamburg was invited to give an invited lecture in the Nanomedicine Translation Research Program.
Prof. Wolfgang Parak gave a lecture entitled with “Quantitative Nanoparticles Analysis in Cells” on September 20, 2022 in Yong loo Lin School of Medicine. His research interest is focused on the nanomaterials for medical treatment and diagnosis. Nanoparticles can be exocytosed from cells, but this highly depends on the properties of the nanoparticles and the type of cells. Prof. Parak discussed the factors that affect the intracellular fate of nanoparticles.
13 September 2022
Prof. Richard P. Baum was invited to give an invited lecture in the Nanomedicine Translation Research Program.
Prof. Baum gave an invited lecture entitled of “Advancing Radio molecular Precision Oncology for Theranostics of Personalised Cancer Care” on September 13, 2022 in Yong loo Lin School of Medicine. He has treated over 5000 patients with more than 10,000 radioligand applications. He received numerous accolades including the Saul Hertz Award, a prestigious nuclear medicine lifetime award. An avid supporter of theranostics with guest professorships around the world, Prof. Baum contributes greatly, clinically and academically, to radiomolecular precision medicine.
2 September 2022
Congratulations to Prof. Chen for receiving the funding support from the Academic Research Council.
Prof. Xiaoyuan Chen has been awarded a 3-year duration ACRF Tier 2 funding from Academic Research Council (ARC), Ministry of Education (MOE). Congratulations!